Fig. 5From: Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicityComparison of splenic lesions in Xh-CL and WT mice following triptolide oral treatment (H&E, ×200). The mice were administered with 0.1 mg/kg (b, e) or 0.2 mg/kg (c, f) triptolide. The control mice received a vehicle (a, d). Mice were dosed every other day for 30 days. Squares indicate bleeding of dilated splenic sinus. Arrows indicate splenic atrophyBack to article page