Fig. 2

Effects of different dosages of DCQD on the inflammatory mediators in kidney tissues of rats with SAP. SG sham operation group, MG model group, LDG low-dose group, MDG medium-dose group, HDG high-dose group. Rats (n = 8 per group) were orally administered different doses of DCQD (6 g/kg in the LDG, 12 g/kg in the MDG, and 24 g/kg in the HDG by body weight) 2 h after operation. After 24 h, the kidney tissues were collected to determine the pro-inflammatory cytokine (IL-6 and TNF-α) and anti-inflammatory cytokine (IL-4 and IL-10) levels. The inflammatory cytokines were measured by ELISA. A IL-4 and IL-6 concentration in kidney tissue. B IL-10 and TNF-α concentration in kidney tissue. The results are expressed as the mean ± SD. ^ap < 0.05 vs. SG and ^bp < 0.05 vs. MG; p > 0.05, ns