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Table 3 The applications of metabolomics in cardiotoxicity evaluation of TCM

From: Application of metabolomics in toxicity evaluation of traditional Chinese medicines

TCM Toxicity Animals Samples Metabolomic technology Data analysis Metabolic pathways References
Periplocin Cardiotoxicity Neonatal rats Cardiomyocytes LC–MS PCA, PLS-DA, Support Vector Machine Amino acid metabolism, energy metabolism, sphingolipid metabolism [73]
Aconitum alkaloids Cardiotoxicity Rats Plasma 1H NMR, GC–MS PCA Energy metabolism, fatty acid metabolism, amino acid metabolism, purine metabolism [74]
Aconiti kusnezoffii Radix Cardiotoxicity Rats Urine LC–MS PCA, PLS-DA, OPLS-DA Pentose and glucuronate interconversions, tryptophan metabolism, amino sugar and nucleotide sugar metabolism, taurine and hypotaurine metabolism, ascorbate and aldarate metabolism, fructose and mannose metabolism, starch and sucrose metabolism [77]
Aconiti Radix Cardiotoxicity Rats Urine LC–MS PCA, PLS-DA, OPLS-DA pentose and glucuronate interconversions, amino acid metabolism, starch and sucrose metabolism, amino sugar and nucleotide sugar metabolism, purine metabolism, tryptophan metabolism, taurine and hypotaurine metabolism, fructose and mannose metabolism, fatty acid metabolism [78, 79]
Aconiti Lateralis Radix Praeparata Cardiotoxicity Rats Plasma LC–MS PCA, PLS-DA, OPLS-DA Sphingolipid metabolism, aminoacyl-tRNA biosynthesis, tryptophan metabolism [80]
Mices Heart LC–MS PCA, PLS-DA Phospholipid metabolism, Sphingolipid metabolism, saturated fatty acid oxidation, unsaturated fatty acid peroxidation [81]
Pinelliae Rhizoma Cardiotoxicity Rats Serum LC–MS PCA, PLS-DA Phospholipid metabolism, amino acid metabolism, carnitine metabolism [83]