Table 3 Metabolomics approach on TCM formulas in treatment of viral pneumonia in animal models
From: Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine
Names | Plants or mineral | Part used | Virus type | Sample material | Detection method | Metabolomics validation (treatment group vs. model group) | References |
|---|---|---|---|---|---|---|---|
Modified Jiu Wei Qiang Huo decoction (MJWQH) | Notopterygium incisum Ting ex H. T. Chang | Root or Rootstalk | H1N1 | Serum | LC–MS | Upregulate: l-valine, O-succinyl-l-homoserine, Downregulate: Lauroyl carnitine, Palmitoyl-l carnitine, l-Ornithine, Uric acid, Taurine, l-Leucine, l-Phenylalanine, PGF2α, 20-ethyl-PGE2, Arachidonic acid, Glycerophospho-N-arachidonoyl Ethanolamine | [60] |
Scutellaria baicalensis Georgi | |||||||
Astragalus membranaceus (Fisch.) Bunge | |||||||
Atractylodes Lancea (Thunb.) DC | |||||||
Saposhnikovia divaricata (Trucz.) Schischk. | |||||||
Taraxacum mongolicum Hand. Mazz | Whole plant | ||||||
Jinxin oral liquid (JOL) | Ephedra sinica Stapf | Stem | RSV | Plasma | GC–MS | Upregulate: Glutamine, Glucose, Arachidonic acid Downregulate: Lactic acid, Urea, 1,5-anhydro-d-sorbitol | |
Prunus armeniaca L. var. ansuMaxim | Seed | ||||||
Urine | GC–MS | Downregulate: Lactic acid, Glycine, Stearic acid, Palmitic acid | |||||
Gypsum Fibrosum | CaSO4·2H2O | ||||||
Spleen | GC–MS | Upregulate: Glutamic acid Downregulate: Proline, Valine, Urea, Glucose, Hypoxanthine | |||||
Scutellaria baicalensis Georgi, | Root or Rootstalk | Plasma | LC–MS | Upregulate: SM(d18:1/24:1), PC(P-20:0/14:0), LysoPC(16:0),LysoPC(18:0), LysoPC(20:4), LysoPC(18:2), LysoPC(18:1), LysoPC(22:6), Phytosphingosine, Downregulate: TG(18:1/18:1/18:2), PE(18:3/19:0) | |||
Polygonum cuspidatum Sieb. etZucc | |||||||
Morus alba L. | |||||||
Peucedanum praeruptorum Dunn | Lung | LC–MS | Upregulate: TG(18:1/18:1/18:1), PC(18:2/20:4), TG(18:1/16:0/20:1), PC(22:6/18:2), Choline, LysoPC(18:0), TG(18:1/18:0/20:1), Leucine, LysoPC(16:0), Phytanicacid, Sphinganine, Phenylalanine, LysoPC(18:1), LysoPC(20:4), LysoPC(18:2), LysoPE(16:0) | ||||
Lepidium apetalum | Seed | ||||||
Mahuang Xixin Fuzi decoction (MXF) | Ephedra sinica Stapf | Stem | H1N1 | Feces | LC–MS | Upregulate: Phosphatidylcholine, Pyridoxal, Lysophosphatidylcholine, Succinic acid, Melatonin Downregulate: Phosphatidylethanolamine, Phosphatidylserine, Oxalacetic acid, l-kynurenine | [61] |
Asarum sieboldii Miq. | Root or Rootstalk | ||||||
Aconitum carmichaeli Debx. | |||||||
Pudilan Xiaoyan Oral Liquid (PDL) | Taraxacum mongolicum Hand-Mazz | Whole plant | H1N1 | Lung | GC–MS | Upregulate: Cytidine, Gluconic acid, Methionine, Xanthine, Xanthosine Downregulate: β-hydroxybutyric acid, Glutaric acid, Sucrose, Thymine, Uridine, Pipecolinic acid, Putrescine | [62] |
Viola yedoensis Makino | |||||||
Isatis indigotica Fort | Root | ||||||
Scutellaria baicalensis Georgi | Root |