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Table 3 DTI-based connectomic analysis in patients with TCM-based subtypes of MDD

From: Brain connectomic associations with traditional Chinese medicine diagnostic classification of major depressive disorder: a diffusion tensor imaging study

Brain regions HC (n = 28) LQS (n = 26) HSD (n = 18) ANCOVA Bonferroni correction t-test
F 2,68 P HC/LQS HC/HSD HSD/LQS
Nodal degree
 Calcarine sulcus 27.3 ± 3.1 24.7 ± 2.9# 25.5 ± 3.2 3.584 0.033 < 0.001 0.279 0.451
 Angular gyrus 11.7 ± 2.0 14.0 ± 3.9* 11.8 ± 2.7* 4.407 0.016 0.062 1.000 < 0.001
Betweenness centrality
 Insula 187.9 ± 142.5 231.5 ± 177.9* 349.7 ± 162.6#* 5.614 0.006 1.000 < 0.001 < 0.001
 Posterior cingulate gyrus 138.6 ± 98.7 185.9 ± 148.0 232.8 ± 147.7# 3.555 0.034 0.480 < 0.001 0.131
 Middle occipital gyrus 183.8 ± 161.5 287.9 ± 173.1* 185.6 ± 131.2* 3.556 0.034 0.094 1.000 0.003
 Heschl’s gyrus 85.3 ± 61.1 166.1 ± 201.7#* 99.2 ± 102.5* 3.497 0.036 < 0.001 1.000 0.007
Clustering coefficient
 Parahippocampal gyrus 0.024 ± 0.009 0.027 ± 0.006 0.031 ± 0.011# 3.206 0.047 0.718 < 0.001 0.081
Fractional anisotropy (FA)
 Frontal medial orbital gyrus 0.217 ± 0.016 0.213 ± 0.020* 0.200 ± 0.015#* 4.580 0.014 1.000 < 0.001 < 0.001
 Middle temporal pole 0.227 ± 0.015 0.228 ± 0.023* 0.215 ± 0.015#* 3.704 0.030 1.000 < 0.001 < 0.001
Mean diffusivity (MD)
 Frontal medial orbital gyrus 0.770 ± 0.034 0.767 ± 0.029* 0.794 ± 0.024#* 4.933 0.010 1.000 < 0.001 < 0.001
  1. Data are expressed as mean ± SD. Analysis of covariance (ANCOVA) was used to detect significance, followed by Bonferroni correction t-test for pairwise comparisons: #P < 0.05, vs. healthy controls; *P < 0.05, between the two subtypes. Those which P values examined with pairwise comparisons are highlighted as red fonts
  2. HC healthy controls, LQS liver qi stagnation subtype, HSD heart and spleen deficiency subtype