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Table 5 Main pharmacokinetic parameters of six analytes in rat plasma after oral administration of the CP extract

From: Simultaneous UPLC–TQ-MS/MS determination of six active components in rat plasma: application in the pharmacokinetic study of Cyclocarya paliurus leaves

Analytes

Parameters

Cmax (ng/ml)

Tmax (h)

t1/2 (h)

AUC0−t (µg/l*h)

AUC0−∞ (µg/l*h)

Neochlorogenic acid

4328.07 ± 1606.86

0.32 ± 0.12

4.54 ± 1.38

2453.18 ± 951.53

2471.38 ± 942.68

Chlorogenic acid

4169.13 ± 1888.68

0.39 ± 0.13

2.54 ± 0.53

3308.80 ± 1062.02

3578.30 ± 1203.93

Quercetin-3-O-glucuronide

3710.01 ± 1593.38

0.33 ± 0.13

10.04 ± 3.31

11,009.41 ± 2173.10

13,455.73 ± 1225.02

Kaempferol-3-O-rhamnoside

263.55 ± 119.77

0.42 ± 0.13

2.42 ± 1.29

553.16 ± 270.45

614.20 ± 254.97

Quercetin

28.60 ± 8.23

0.46 ± 0.10

11.70 ± 6.01

79.83 ± 28.49

91.68 ± 15.20

Kaempferol

121.82 ± 49.87

0.67 ± 0.26

7.24 ± 1.63

241.77 ± 76.98

324.73 ± 104.26

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Chinese Medicine

ISSN: 1749-8546

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