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Table 5 Main pharmacokinetic parameters of six analytes in rat plasma after oral administration of the CP extract

From: Simultaneous UPLC–TQ-MS/MS determination of six active components in rat plasma: application in the pharmacokinetic study of Cyclocarya paliurus leaves

Analytes Parameters
Cmax (ng/ml) Tmax (h) t1/2 (h) AUC0−t (µg/l*h) AUC0−∞ (µg/l*h)
Neochlorogenic acid 4328.07 ± 1606.86 0.32 ± 0.12 4.54 ± 1.38 2453.18 ± 951.53 2471.38 ± 942.68
Chlorogenic acid 4169.13 ± 1888.68 0.39 ± 0.13 2.54 ± 0.53 3308.80 ± 1062.02 3578.30 ± 1203.93
Quercetin-3-O-glucuronide 3710.01 ± 1593.38 0.33 ± 0.13 10.04 ± 3.31 11,009.41 ± 2173.10 13,455.73 ± 1225.02
Kaempferol-3-O-rhamnoside 263.55 ± 119.77 0.42 ± 0.13 2.42 ± 1.29 553.16 ± 270.45 614.20 ± 254.97
Quercetin 28.60 ± 8.23 0.46 ± 0.10 11.70 ± 6.01 79.83 ± 28.49 91.68 ± 15.20
Kaempferol 121.82 ± 49.87 0.67 ± 0.26 7.24 ± 1.63 241.77 ± 76.98 324.73 ± 104.26