Table 2 Identified metabolites of the serum from different groups
No. | R.T. (min) | Mass (m/z) | Metabolites | Formula | KEGG | Change trend | Pathway | |
|---|---|---|---|---|---|---|---|---|
Control/model | Model/AR | |||||||
1 | 14.174 | 624.281 | Leukotriene C4 | C30H47N3O9S | C02166 | Down | Up | Arachidonic acid metabolism |
2 | 14.224 | 544.339 | LysoPC(18:1 (9Z)) | C26H52NO7P | C04230 | Down | Up | Glycerophospholipid metabolism |
3 | 16.987 | 524.371 | 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine | C26H54NO7P | C04598 | Down | Up | Ether lipid metabolism |
4 | 10.064 | 371.235 | 6-Keto-prostaglandin F1a | C20H34O6 | C05961 | Up | Down | Arachidonic acid metabolism |
5 | 14.609 | 498.335 | Taurochenodesoxycholic acid | C26H45NO6S | C05465 | Down | Up | Primary bile acid biosynthesis |
6 | 16.363 | 343.224 | 5,6-Epoxy-8,11,14-eicosatrienoic acid | C20H32O3 | C14768 | Down | Up | Arachidonic acid metabolism |
7 | 16.030 | 532.340 | LysoPC(O-18:0) | C26H56NO6P | C04317 | Down | Up | Ether lipid metabolism |
8 | 18.113 | 322.269 | Sphingosine | C18H37NO2 | C00319 | Down | Up | Sphingolipid metabolism |
9 | 18.150 | 322.270 | 3-Dehydrosphinganine | C18H37NO2 | C02934 | Down | Up | Sphingolipid metabolism |