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Table 5 Effects of timosaponin BII and timosaponin BIII on the content of 5-HT and DA

From: Identifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests

Groups Dosage (mg/kg) Content (ng/g)
5-HT DA
Control 636.2 ± 80.1 171.6 ± 54.5
Fluoxetine 10 731.3 ± 104.6* 215.9 ± 36.5*
Timosaponin BII 10 716.5 ± 90.4* 196.9 ± 56.7
Timosaponin BIII 10 705.6 ± 47.7* 191.3 ± 69.8
  1. 5-HT and DA represented serotonin and dopamine, respectively
  2. * P < 0.05 compared with blank group