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Table 1 Examples of TCM regulating pathological EMT [19, 133]

From: Traditional Chinese Medicine and regulatory roles on epithelial–mesenchymal transitions

Wenyang Huazhuo Tongluo formula Wnt/β-catenin Skin fibrosis [46]
Salvia miltiorrhiza and ligustrazine TNF-α and TGF-β Pulmonary fibrosis [47]
Genistein IL-6, TNFα, myeloperoxidase SFRP1 and SMAD4 Hepatic fibrosis [18] Prostate cancer [127]
Betulin TNF-α, TGF-β1, TIMP-1, TIMP-2/MMP-2 Liver fibrosis [19]
Silybinin TGF-β1/oxidase stress Liver fibrosis [133]
Diwu Yanggan formula Modulated the EMT and MET balance Liver fibrosis [44]
Salvianolic acid B Abrogated EMT-induced fibrogenesis Renal fibrosis [134]
Fuzheng Huayutablet α-SMA, TGF-β1, and SMAD3 Renal fibrosis [135]
Handan Ganle Modulated the EMT and MET balance Liver fibrosis [136]
Shikonin Stimulate EMT related microRNAs Skin wound healing [55]
Tanshinone IIA TLR4/MYD88/NF-κB Ventricular remodeling [56]
Curcumin TGF‐β/SMAD and SNAIL; PI3 K/AKT/mTOR; PPARγ Renal fibrosis [45] /hepatocellular [89] /lung carcinoma [137]
Polyphyllin I IL-6/STAT3 Non-small-cell lung cancer [138]
Ginsenoside Rg3 NF-κB Lung cancer [69]
Matrine ROS/NF-κB/MMPs Pancreatic cancer [117]
Toosendanin AKT/mTOR Pancreatic cancer [139]
Brucine MMP-2 and MMP-9 Breast cancer [140]
Yiqi Huayu Jiedu decoction TGF‐β/SMAD Gastric cancer [141]
Yi Ai Fang HIF‐1α Colorectal cancer [116]
Jianpi Huayu decoction SMAD3/SMAD7 Hepatocellular carcinoma [90]
Resveratrol LPS‑induced EMT Prostate cancer [70]
Triptolide MMP‐7 and MMP‐19 Ovarian cancer [51]
Thymoquinone TWIST1/ZEB1/E-cadherin Cervical cancer [72]
Shaoyao decoction IL1β, IL6, TNF-α, tumor-associated macrophages, and p65 Colorectal cancer [94]
Qingyihuaji formula Tumor-associated macrophage and IL-6 Pancreatic cancer [67]
Sheng Qi formula Myeloid immune-suppressor cells (MDSC) Breast cancer [81]
Feiyanning decoction CD4+ CD25+ regulatory T cells Lewis lung carcinoma [80]
Ginsenoside Rb1 MicroRNA (mir)-25 Ovarian cancer [66]
Jin-Fu-An decoction P120ctn, isoform 1A Lung cancer [129]