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Table 1 Secondary metabolites of Chaetomium in Ginkgo biloba

From: Endophytes from Ginkgo biloba and their secondary metabolites

No.MetabolitesCAS numberMolecular structureEndophytesApplicationReferences
1(22E, 24R)-ergosta-7,22-diene-3β,5α,6β-triol/cerevisterol516-37-0 Chaetomium globosum [33]
2(22E, 24R)-ergosta-7,22-diene-3β,5α,6β,9α-tetraol88191-06-4 Chaetomium globosum [44]
3(7Z,11E)-7,11-Hexadecadien-1-yl acetate53042-79-8 Chaetomium globosum No. 16Pesticide[45]
4(E,E)-2,4-Decadienal25152-84-5 Chaetomium globosum No. 16Food_additive; fragrance[45]
5(Z)-9-Hexadecenoic acid, methyl ester1120-25-8 Chaetomium globosum No. 16 [45]
6(Z,Z)-9,12-Octadecadienoic acid60-33-3 Chaetomium globosum No. 16Biosynthesis of prostaglandins and cell membranes[45]
71-(3-Acetyl-2,2-dimethylcyclopropyl)-2-methyl-1-propanone77142-84-8 Chaetomium globosum T16 [49]
81-(3-Methoxy-2-pyrazinyl)-2-methyl-1-propanone98618-81-6 Chaetomium globosum T16 [46]
91,3-Dioxolane, 2-methoxy19693-75-5 Chaetomium globosum T16 [46]
101-Eicosene3452-07-1 Chaetomium globosum No. 16 [45]
111-Trimethylsilyl methanol3219-63-4 Chaetomium globosum T16 [46]
122,3,4-Trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran1824584-79-3 Chaetomium globosum [47]
132,4,5-Trimethyl-1,3-dioxolane3299-32-9 Chaetomium globosum T16Flavors[46]
142,4-Decadienal2363-88-4 Chaetomium globosum No.16Food additive[20, 21]
152′-O-Methyladenosine2140-79-6 Chaetomium globosumInhibition of vaccinia virus growth[47]
162′-Deoxyadenosine958-09-8 Chaetomium globosumAnti-tumor and antiviral nucleoside drugs (cladribine)[44]
1720-Dihydrochaetoglobosin A149560-98-5 Chaetomium globosum [47]
1821 Methoxy-Chaetoglobosin F  Chaetomium globosum [47]
182-Cyclohexyl-hex-5-en-2-ol959261-17-7 Chaetomium globosum T16 [46]
192-Ethyl-5-propylphenol72386-20-0 Chaetomium globosum T16 [46]
202-Methyl-5-propyl-2,4-dihydro-3H-pyrazol-3-one31272-04-5 Chaetomium globosum T16 [46]
212-Octyl-cyclopropaneoctanal56196-06-6 Chaetomium globosum No.16 [45]
223,4-Dihydroxyphenyl acetic acid102-32-9 Chaetomium globosumA metabolite of dopamine, Cytoplasm, Encephalitis, Hypothyroidism, Alzheimer’s disease, Colorectal cancer[47]
233-Methylorsellinic acid4707-46-4 Chaetomium globosum ZY-22Neuroprotective Activity[46]
244-Aminophenylacetic acid/p-aminophenylacetic acid/4-aminophenylacetic acid1197-55-3 Chaetomium globosumAnti-inflammatory Inhibition colitis[47]
254-Methyl-1-hepten-5-one26118-97-8 Chaetomium globosum [46]
265-(hydroxymethyl)-1H-pyrrole-2-carbaldehyde67350-50-9 Chaetomium globosumHapten, produces advanced glycation end-products (AGEs)[47]
275′-Epichaetovirdin A1308671-17-1 Chaetomium globosum No. 12 [45]
285′-Deoxy-5′-methylamino-adenosineNo cas no. Chaetomium globosum [47]
299(11)-dehyoergosterol peroxide86363-50-0 Chaetomium globosum ZY-22 [44]
309,12-Octadecadien-1-ol1577-52-2 Chaetomium globosum No. 16 [45]
31Acetaldehyde, diethyl acetal105-57-7 Chaetomium globosum T16Used in fruit, rum and whisky flavour[46]
32Adenosine58-61-7 Chaetomium globosum ZY-22Vasodilatory, anti-arrhythmic and analgesic activities adenosine is an adenosine receptor agonist[46]
33Allantoin97-59-6 Chaetomium globosumHealing, soothing, and anti-irritating properties anti-acne products, sun care products, and clarifying lotions [48]
34alpha-Methylstyrene98-83-9 Chaetomium globosumMembrane adhesives and sealant chemicals[48]
35Anthranilic acid118-92-3 Chaetomium globosum MX-0510A water-soluble vitamin[33]
36Benzeneacetic acid103-82-2 Chaetomium globosum No. 16Used in the manufacture of penicillin and bendazol[45]
37Benzeneacetic acid, methyl ester101-41-7 Chaetomium globosum No. 16Used in the manufacture of atropine[45]
38Benzeneethanol/phenylethyl alcohol60-12-8 Chaetomium globosumEssence[45]
39Butyraldehyde, 4-phenyl18328-11-5 Chaetomium globosum T16 [46]
40Cerebroside B88642-46-0 Chaetomium globosum ZY-22 [46]
41Cerebroside C98677-33-9 Chaetomium globosum ZY-22 [46]
42Chaetoglobosin A50335-03-0 Chaetomium globosum [44, 49]
43Chaetoglobosin B50335-04-1 Chaetomium globosum CDW7 [48]
44Chaetoglobosin C50645-76-6 Chaetomium globosum [26, 28]
45Chaetoglobosin D55945-73-8 Chaetomium globosum [49]
46Chaetoglobosin E55945-74-9 Chaetomium globosum (CDW7) [49]
47Chaetoglobosin F55945-75-0 Chaetomium globosum (CDW7) [47]
48Chaetoglobosin Fa1599426-06-8 Chaetomium globosum [47]
49Chaetoglobosin Fex149457-95-4 Chaetomium globosum [47]
50Chaetoglobosin G65773-98-0 Chaetomium globosum (NM0066) [47]
51Chaetoglobosin R777939-30-7 Chaetomium globosum [49]
52Chaetoglobosin V1399682-37-1 Chaetomium globosum [47]
53Chaetoglobosin Vb1399690-75-5 Chaetomium globosum (CDW7) [48]
54Chaetoglobosin Y1608108-89-9 Chaetomium globosum [48]
55Chaetomugilide A1418138-71-2 Chaetomium globosum [45, 47]
56Chaetomugilide B1433976-48-7 Chaetomium globosum [45]
57Chaetomugilide C1418138-70-1 Chaetomium globosum [45, 47]
58Chaetomugilin A1041640-66-7 Chaetomium globosum [45]
59Chaetomugilin D1098081-38-9 Chaetomium globosum [25]
60Chaetomugilin I1187848-00-5 Chaetomium globosum [25]
61Chaetomugilin J1187848-01-6 Chaetomium globosum [25]
62Chaetomugilin O1187848-06-1 Chaetomium globosum [25]
63Chaetomugilin Q1319729-85-5 Chaetomium globosum [25]
64Chaetomugilin S1399093-77-6 Chaetomium globosum [25]
65Chaetoviridin C128230-02-4 Chaetomium globosum [15]
66Chaetoviridin D128230-04-6 Chaetomium globosum [33]
67Chaetoviridin E1178875-15-4 Chaetomium globosum [33]
68Cyclo-(Phe-Gly)5037-75-2 Chaetomium globosum [33]
69Cyclopentadecane295-48-7 Chaetomium globosum No.16 [45]
70Dimethyl phthalate131-11-3 Chaetomium globosum No.16Used in plastics, insect repellents, safety glass, and lacquer coatings[45]
71Epimwsokorwnone A1073-96-7 Chaetomium globosum [33]
72Ergosta-4 6,8,22-tetraen-3-one/ergosta-4,6,8,22-tetraen-3-one194721-75-0 Chaetomium globosum (ZY-22) [33]
73Ergosterol57-87-4 Chaetomium globosumFormation of vitamin D2[49]
74Ergosterol peroxide (5α,8α-epi-dioxy-(22E,24R) -ergosta-6,22-dien-3β-ol)2061-64-5 Chaetomium globosumAn antineoplastic agent, an antimycobacterial drug and a trypanocidal drug[33]
75Ethanoic acid64-19-7 Chaetomium globosum T16Food additive, and in petroleum production[46]
76Ethyl 13-methyl-tetradecanoate64317-63-1 Chaetomium globosum No. 16 [45]
77Ethyl 2-heptenoate2351-88-4 Chaetomium globosum T16 [45]
78Ethylidene acetate542-10-9 Chaetomium globosum T16 [45]
79flavipin (1,2-benzenedicarboxaldehyde-3,4,5-trihydroxy-6-methyl)483-53-4 Chaetomium globosum CDW7Antioxidant fungicides[22]
80Fumigaclavine B6879-93-2 Chaetomium globosum [47]
81Fumitremorgin C118974-02-0 Chaetomium globosum (NM0066)A mycotoxin and a breast cancer resistance protein inhibitor[33]
82Gliotoxin67-99-2 Chaetomium globosum (NM0066)A mycotoxin, an immunosuppressive agent, an protein farnesyltransferase inhibitor, a proteasome inhibitor and an antifungal agent[33]
83Globosterol1193319-70-8 Chaetomium globosum ZY-22 [44]
84Glycerol formal5464-28-8 Chaetomium globosum T16 [46]
85Hexadecane544-76-3 Chaetomium globosumUsed as a solvent and an ingredient in gasoline and diesel and jet fuels[45]
86Hexadecanoic acid, ethyl ester628-97-7 Chaetomium globosum No. 16Used as softener, lubricant, food additive[45]
87Hexadecanoic acid, methyl ester112-39-0 Chaetomium globosum No. 16Used as intermediate of emulsifier, wetting agent, stabilizer and plasticizer[45]
88Indole-3- carboxylic acid771-50-6 Chaetomium globosum ZY-22Used for synthesis of to rise tron and antiviral drugs[33]
89Indole-3-acetic acid87-51-4 Chaetomium globosumPlant growth stimulating hormone[33]
90Isopentyl alcohol, acetate123-92-2 Chaetomium globosum T16Used as a solvent and preparation of a variety of flavor food flavor[22]
91Lactic acid50-21-5 Chaetomium globosum T16Used to make some plasticizers, adhesives, pharmaceuticals and salts, used in the leather tanning industry and as a solvent[46]
92Lactic acid, 2-methyl-,ethyl ester80-55-7 Chaetomium globosum T16 [46]
93Maltol118-71-8 Chaetomium globosum MX-0510Food additive[33]
94Mannitol87-78-5 Chaetomium globosumUsed as an osmotic diuretic[33]
95Methyl 13-methyltetradecanoate5129-59-9 Chaetomium globosum No. 16 [45]
96Methyl 9,12-heptadecadienoate15620-59-4 Chaetomium globosum No. 16 [45]
97Methyl vinylcarbinol598-32-3 Chaetomium globosumFood additive[46]
98Methylthiogliotoxin74149-38-5 Chaetomium globosum (NM0066) [33]
99o-Coumaric acid583-17-5 Chaetomium globosum ZY-22An antioxidant and is believed to reduce the risk of stomach cancer by reducing the formation of carcinogenic nitrosamines[33]
100Octanoic acid, methyl ester111-11-5 Chaetomium globosum No. 16Food additive[45]
101Pentadecane629-62-9 Chaetomium globosum No. 16Used as a solvent and in some household pesticides[45]
102Pentadecanoic acid, methyl ester7132-64-1 Chaetomium globosum No. 16Fuels and fuel additives
Intermediates, pesticide
103p-Hydroxybenzoic acid99-96-7 Chaetomium globosumUsed as preservatives, fungicides[33]
104Pseurotin A58523-30-1 Chaetomium globosum (NM0066)An azaspiro compound, an oxaspiro compound and a lactam[33]
105Quercetin117-39-5 Chaetomium globosum GCZX015Combined with chemotherapeutic drugs, produces anti-inflammatory and anti-allergy effects[33]
106Squalene111-02-4 Chaetomium globosum (NM0066)Investigated as an adjunctive cancer therapy, also used as cosmetics and dietary supplement[33]
107S-Tetrachloroethane79-34-5 Chaetomium globosum T16Used to make paint, varnish and rust removers, as a solvent and as an ingredient in pesticides[45]
108Succinic acid110-15-6 Chaetomium globosumA radiation protective agent, an anti-ulcer drug[33]
109Tetradecane629-59-4 Chaetomium globosum No.16Used as a solvent and some pesticide sprays[45]
110Thymine65-71-4 Chaetomium globosum ZY-22A pyrimidine nucleobase and a pyrimidone[33]
111Tridecane629-50-5 Chaetomium globosum No. 16Used as a solvent and as an ingredient in gasoline and diesel and jet fuel[45]
112Triethylene glycol monomethyl ether acetate3610-27-3 Chaetomium globosum T16 [46]
113Uracil66-22-8 Chaetomium globosum ZY-22Use in the body to help synthesis of many enzymes, and the biosynthesis of polysaccharides and the transportation of sugars containing aldehydes[49]
114α-Guajene3691-12-1 Chaetomium globosum No. 16 [45]