Skip to main content

Table 1 The inhibitory effects of ginsenosides on human carboxylesterases in HLM

From: Inhibition of human carboxylesterases by ginsenosides: structure–activity relationships and inhibitory mechanism

No.CompoundsMWIC50 (μM)Specificity (hCES1A/hCES2A)
hCES1AhCES2A
1DM444.401.99 ± 0.210.69 ± 0.083.06
2C-K622.44> 10015.46 ± 1.56> 6.47
3Rh2622.44> 1005.35 ± 0.56> 18.86
4DMG606.451.76 ± 0.281.06 ± 0.210.33
5R1932.53> 100> 100
6F2478.03> 10014.37 ± 1.597.26
7Panaxadiol460.396.95 ± 1.293.78 ± 0.391.84
8PPD460.39> 1001.34 ± 0.11> 75.18
9Panaxatriol476.3934.93 ± 6.1614.59 ± 1.092.39
10PPT476.39> 1000.86 ± 0.09> 116.28
11Rb11108.60> 100> 100
12Rg2784.50> 100> 100
13Rc1078.59> 10081.66 ± 18.56>1.22
14Rb21078.59> 100> 100
15Re946.55> 100> 100
16Rh1638.88> 100> 100
17Rg3784.50> 10010.37 ± 1.17> 9.64
18Rb31078.59> 100> 100
19F1638.44> 10037.08 ± 5.09> 2.70
20Rg1800.49> 100> 100
21Rd946.55> 10014.05 ± 1.78> 7.12
22Ro956.50> 100> 100
23F4766.49> 10045.02 ± 6.48> 2.22
24Rh3604.43> 1005.85 ± 1.17> 17.09
25Rh4620.43> 10062.85 ± 6.72> 1.49