Fig. 8

EOFAZ inhibited p-CREB and p-CaMKII in RMCs induced by HG via activating PPAR-γ. RGZ (a, b), overexpression of plasmid (c, d), and GW9662 (e, f) or PPAR-γ siRNA (g, h) were used alone or combined with EOFAZ in RMCs. The level of p-CREB and p-CaMK II and the expression of total CREB and CaMK II was detected via Western blot analysis. Data are expressed as mean ± SEM. n = 3. *P < 0.05, **P < 0.01 vs. control group, ^#P < 0.05, ^##P < 0.01 vs. HG group, ^$P < 0.05 vs.HG + EOFAZ group