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Table 1 Characterization of ZYD prototype components in vivo by HPLC-ESI-Q-TOF-MS/MS

From: Systematic analysis and identification of the absorption and metabolic components of Zengye decoction in type 2 diabetic rats by HPLC-ESI-Q-TOF–MS/MS

Peak No.tR(min)Precursor ions (m/z)FormulaError (mDa)Fragment ionsIdentificationPUFBRefs.
ExperimentalTheoretical
P110.332407.1282*407.1195C17H22O10− 8.70361.1038, 199.0607, 181.0507, 169.0505Catalpol+++[10]
P220.658391.1284*391.1246C15H22O19− 3.81211.1011, 183.0662, 165.0543, 139.0410Aucubin+++[10]
P423.285731.2325*731.2251C27H42O20− 7.35685.2276, 505.1599, 341.1118, 179.0561Rehmannioside D++[10]
P525.065409.1384*409.1351C15H24O10− 3.05201.0771, 183.0663, 165.0556, 157.0504Harpagide++++[10]
P626.149393.1443*393.1402C15H24O9− 4.06185.0560, 179.0526, 167.0716, 113.0238Leonuride++++[10]
P829.733373.1216373.1140C16H22O10− 7.58331.0989, 221.0893, 167.0426, 149.0622Geniposidic acid++[18]
P930.113421.1332*421.1351C16H24O101.95213.0732, 195.0662, 183.0657, 169.04376-O-methylcatalpol++++[19]
P1030.783461.1698461.1664C20H30O12− 3.35461.1698Decaffeoylacteoside+[10]
P1131.790375.1317375.1297C16H24O102.03375.13178-epilogonic acid++[9]
P1236.172487.1527487.1457C21H28O13− 6.99487.1527Cistanoside F+[10]
P1441.765313.0938313.0929C14H18O8− 0.91313.0938, 229.1749, 137.0605, 123.0439Rhamnopyranosyl vanilloyl+[20]
P1542.066475.1845475.1821C21H32O12− 2.4475.1845Darendoside B+[10]
P1643.203607.2290607.2244C26H40O16− 4.64607.2298, 475.1859, 461.1697, 443.1586, 149.0457, 131.0351β-(3-hydroxy-4-methoxyhenyl) ethyl-O-α-L-arabinopyranosyl-(1 → 6)-O-[6-α-L-rhamnpyranosyl-(1 → 3)-β-D-glucopyranoside++[10]
P2049.444183.1028183.1027C10H16O3− 0.13183.1036, 139.1123, 123.0792Rehmapicrogenin++++[10]
P2354.309435.2269*435.2236C19H34O8− 3.33389.2370, 179.0539, 161.0451, 119.0348Rehmaionoside A/B++[10]
P2656.018799.2778799.2666C36H48O20− 11.18799.2778Jionoside A1/A2++[21]
P2456.295163.0399163.0401C9H8O30.17145.0270, 119.0499p-coumaric acid+++[10]
P2960.152193.0511193.0500C10H10O4− 0.47178.0269, 149.0598, 134.0369, 121,0282Ferulic acid++[10]
P3161.894623.2049623.1981C29H36O15− 6.76461.1676, 315.1084, 161.0241, 135.0445Acteoside+[10]
P3463.221769.2634769.2561C35H46O19− 7.35769.2634Scrophuloside B1/B2+[22]
P3663.473623.2021623.1981C29H36O15− 3.96623.2021Isoacteoside or Forsythoside A+[10]
P3765.538525.1665525.1614C24H30O13− 5.14525.16658-O-caffeoyl harpagide+[19]
P3967.938429.2171429.2130C21H34O9− 4.09249.1512, 231.1370, 187.1472Jiocarotenoside A1/A2++[23]
P4169.475783.2798783.2717C36H48O19− 8.10607.2294, 589.2154, 461.1666, 193.0500Angoroside C++[10]
P4270.273783.2840783.2717C36H48O19− 12.30783.2840, 829.4135Isoangoroside C++[10]
P4770.428637.2199637.2138C30H38O15− 6.11461.1706, 193.0512, 149.0577, 134.0372Leucosceptoside A+[21]
P5275.561651.2397651.2294C31H40O15− 10.26651.2397Cistanoside D+[24]
P5579.343539.1823*539.1770C24H30O11− 5.29493.1715, 345.1210, 183.0662, 165.0556Harpagoside+++[10]
P5681.455147.0450147.0452C9H8O20.15147.0450Cinnamic acid++[10]
P6298.429345.1014345.0980C18H18O7− 3.42345.10145,7,2′,4′-tetradihydroxy-8-methoyl-6-methyl-homoisoflavanone+[10]
P74104.020359.1161359.1136C19H20O7− 2.47359.1161Ophiopogonanone E++[10]
P75105.884343.1215343.1187C19H20O6− 2.79343.12155-7-4′-trihydroxy-5′-methoxy-6,8-dimethyl hamoisoflavanone+[25]
P77107.848327.0905327.0874C18H16O6− 3.09327.0905Ophiopogonone A+[10]
P78110.065339.0898339.0874C19H16O6− 2.39339.0898Methylophiopogone A++[10]
P79110.853341.1059341.1031C19H18O6− 2.84206.0587, 178.0258Methylophiopogonanone A+[10]
P80111.626327.1260327.1238C19H20O5− 2.20327.1260Methylophiopogone B+[10]
  1. a), tR, retention time; *, [M+HCOOH−H], other, [M−H]; P, plasma; U, urine; F, feces; B, bile. +, containing; −, not