Skip to main content

Table 2 Observed and Fitted Group Assessment of CINV in Each Group

From: Efficacy of acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting in patients with advanced cancer: a multi-center, single-blind, randomized, sham-controlled clinical research

a. CTCAE assessment of CINV
 Mean (SD)
True acupuncture group (n = 62)
Sham acupuncture group (n = 58)P value
Nausea
Baseline0.56 (0.692)0.40 (0.528)0.244
Day 10.82 (0.779)0.67 (0.636)0.326
Day 20.92 (0.685)0.91 (0.779)0.921
Day 30.87 (0.735)1.02 (0.761)0.288
Day 7 (± 1)0.60 (0.689)0.71 (0.622)0.257
Day 10 (± 1)0.37 (0.579)0.48 (0.655)0.355
Day 14 (± 1)0.31 (0.531)0.40 (0.591)0.388
Day 21 (± 1)0.18 (0.426)0.39 (0.620)0.041*
Vomiting
Baseline0.29 (0.555)0.16 (0.451)0.096
Day 10.52 (0.695)0.30 (0.533)0.078
Day 20.50 (0.741)0.60 (0.771)0.403
Day 30.50 (0.647)0.57 (0.704)0.656
Day 7 (± 1)0.29 (0.584)0.34 (0.579)0.394
Day 10 (± 1)0.19 (0.438)0.36 (0.693)0.177
Day 14 (± 1)0.21 (0.484)0.31 (0.681)0.499
Day 21 (± 1)0.10 (0.349)0.23 (0.598)0.183
b. Completed control rate of CINV
 No. (%)
True acupuncture group (n = 62)
Sham acupuncture group (n = 58)P value
Nausea
Baseline34 (54.8)36 (62.1)0.422
Day 125 (40.3)24 (41.4)0.906
Day 217 (27.4)20 (34.5)0.402
Day 321 (33.9)16 (27.6)0.456
Day 7 (± 1)32 (51.6)22 (37.9)0.132
Day 10 (± 1)42 (67.7)35 (60.3)0.398
Day 14 (± 1)45 (72.6)38 (65.5)0.402
Day 21 (± 1)52(83.9)39 (67.2)0.033*
Vomiting
Baseline47 (75.8)51 (87.9)0.086
Day 137 (59.7)42 (72.4)0.142
Day 239 (62.9)32 (55.2)0.389
Day 335 (56.5)32 (55.2)0.888
Day 7 (± 1)48 (77.4)40 (69.0)0.295
Day 10 (± 1)51 (82.3)42 (72.4)0.197
Day 14 (± 1)51 (82.3)45 (77.6)0.523
Day 21 (± 1)57 (91.9)48 (82.8)0.214
c. Variation of CINV degree evaluated by CTCAE in each group
 Mean (SD)
True acupuncture group (n = 62)
Sham acupuncture group (n = 58)P value
Nausea
Day 10.258 (0.599)0.259 (0.609)0.996
Day 20.355 (0.546)0.517 (0.755)0.182
Day 30.306 (0.616)0.621 (0.834)0.021*
Day 7 (± 1)0.032 (0.724)0.310 (0.654)0.030*
Day 10 (± 1)− 0.194 (0.649)0.086 (0.539)0.011*
Day 14 (± 1)− 0.258 (0.676)0.000 (0.375)0.011*
Day 21 (± 1)− 0.387 (0.662)− 0.017 (0.477)0.001*
Vomiting
Day 10.226 (0.556)0.138 (0.348)0.298
Day 20.210 (0.631)0.448 (0.776)0.068
Day 30.210 (0.604)0.414 (0.676)0.085
Day 7 (± 1)0.000 (0.444)0.190 (0.512)0.033*
Day 10 (± 1)− 0.097 (0.503)0.207 (0.585)0.003*
Day 14 (± 1)− 0.081 (0.552)0.155 (0.556)0.021*
Day 21 (± 1)− 0.194 (0.507)0.069 (0.454)0.003*
  1. CINV Chemotherapy Induced Nausea and Vomiting, CTCAE the Common Terminology Criteria for Adverse Events, SD standard deviation
  2. *P values are based on independent-samples t tests comparing differences in between-group means