Efficacy of acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting in patients with advanced cancer: a multi-center, single-blind, randomized, sham-controlled clinical research

Table 2 Observed and Fitted Group Assessment of CINV in Each Group

*a. CTCAE assessment of CINV*
	Mean (SD) True acupuncture group (n = 62)	Sham acupuncture group (n = 58)	P value
*Nausea*
Baseline	0.56 (0.692)	0.40 (0.528)	0.244
Day 1	0.82 (0.779)	0.67 (0.636)	0.326
Day 2	0.92 (0.685)	0.91 (0.779)	0.921
Day 3	0.87 (0.735)	1.02 (0.761)	0.288
Day 7 (± 1)	0.60 (0.689)	0.71 (0.622)	0.257
Day 10 (± 1)	0.37 (0.579)	0.48 (0.655)	0.355
Day 14 (± 1)	0.31 (0.531)	0.40 (0.591)	0.388
Day 21 (± 1)	0.18 (0.426)	0.39 (0.620)	0.041*
*Vomiting*
Baseline	0.29 (0.555)	0.16 (0.451)	0.096
Day 1	0.52 (0.695)	0.30 (0.533)	0.078
Day 2	0.50 (0.741)	0.60 (0.771)	0.403
Day 3	0.50 (0.647)	0.57 (0.704)	0.656
Day 7 (± 1)	0.29 (0.584)	0.34 (0.579)	0.394
Day 10 (± 1)	0.19 (0.438)	0.36 (0.693)	0.177
Day 14 (± 1)	0.21 (0.484)	0.31 (0.681)	0.499
Day 21 (± 1)	0.10 (0.349)	0.23 (0.598)	0.183

*b. Completed control rate of CINV*
	No. (%) True acupuncture group (n = 62)	Sham acupuncture group (n = 58)	P value
*Nausea*
Baseline	34 (54.8)	36 (62.1)	0.422
Day 1	25 (40.3)	24 (41.4)	0.906
Day 2	17 (27.4)	20 (34.5)	0.402
Day 3	21 (33.9)	16 (27.6)	0.456
Day 7 (± 1)	32 (51.6)	22 (37.9)	0.132
Day 10 (± 1)	42 (67.7)	35 (60.3)	0.398
Day 14 (± 1)	45 (72.6)	38 (65.5)	0.402
Day 21 (± 1)	52(83.9)	39 (67.2)	0.033*
*Vomiting*
Baseline	47 (75.8)	51 (87.9)	0.086
Day 1	37 (59.7)	42 (72.4)	0.142
Day 2	39 (62.9)	32 (55.2)	0.389
Day 3	35 (56.5)	32 (55.2)	0.888
Day 7 (± 1)	48 (77.4)	40 (69.0)	0.295
Day 10 (± 1)	51 (82.3)	42 (72.4)	0.197
Day 14 (± 1)	51 (82.3)	45 (77.6)	0.523
Day 21 (± 1)	57 (91.9)	48 (82.8)	0.214

*c. Variation of CINV degree evaluated by CTCAE in each group*
	Mean (SD) True acupuncture group (n = 62)	Sham acupuncture group (n = 58)	P value
*Nausea*
Day 1	0.258 (0.599)	0.259 (0.609)	0.996
Day 2	0.355 (0.546)	0.517 (0.755)	0.182
Day 3	0.306 (0.616)	0.621 (0.834)	0.021*
Day 7 (± 1)	0.032 (0.724)	0.310 (0.654)	0.030*
Day 10 (± 1)	− 0.194 (0.649)	0.086 (0.539)	0.011*
Day 14 (± 1)	− 0.258 (0.676)	0.000 (0.375)	0.011*
Day 21 (± 1)	− 0.387 (0.662)	− 0.017 (0.477)	0.001*
*Vomiting*
Day 1	0.226 (0.556)	0.138 (0.348)	0.298
Day 2	0.210 (0.631)	0.448 (0.776)	0.068
Day 3	0.210 (0.604)	0.414 (0.676)	0.085
Day 7 (± 1)	0.000 (0.444)	0.190 (0.512)	0.033*
Day 10 (± 1)	− 0.097 (0.503)	0.207 (0.585)	0.003*
Day 14 (± 1)	− 0.081 (0.552)	0.155 (0.556)	0.021*
Day 21 (± 1)	− 0.194 (0.507)	0.069 (0.454)	0.003*

CINV Chemotherapy Induced Nausea and Vomiting, CTCAE the Common Terminology Criteria for Adverse Events, SD standard deviation
*P values are based on independent-samples t tests comparing differences in between-group means

ISSN: 1749-8546