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Table 6 The main pharmacokinetic parameters of 19 FKQJF compounds in plasma of rats

From: An effective UFLC–MS/MS method used to study pharmacokinetics of major constituents of Fukeqianjin formula in rat plasma

Analyte

AUC0→t (ng h/mL)

AUC0→∞ (ng h/mL)

MRT0→t (h)

MRT0→∞ (h)

t1/2 (h)

Tmax (h)

Cmax (ng/mL)

1

108.74 ± 11.40

115.09 ± 15.76

2.60 ± 0.12

3.37 ± 0.26

1.79 ± 0.44

2.00 ± 0.00

47.99 ± 4.41

2

2967.61 ± 169.49

3110.48 ± 38.66

6.51 ± 0.66

8.09 ± 1.32

5.27 ± 2.94

2.17 ± 0.76

477.02 ± 33.31

3

463.00 ± 29.50

489.12 ± 37.60

3.67 ± 0.14

4.32 ± 0.47

2.66 ± 0.69

2.33 ± 0.58

101.53 ± 18.42

4

80.47 ± 9.64

92.61 ± 21.43

2.38 ± 0.24

3.25 ± 0.41

2.20 ± 1.24

1.00 ± 0.50

46.84 ± 6.78

5

344.22 ± 43.08

504.72 ± 108.63

3.51 ± 0.24

7.55 ± 1.93

3.89 ± 0.85

1.00 ± 0.43

103.90 ± 14.93

6

466.39 ± 51.94

1012.04 ± 558.43

9.19 ± 1.00

13.95 ± 9.49

10.49 ± 6.63

0.08 ± 0.00

79.85 ± 9.43

7

468.14 ± 48.36

550.30 ± 70.65

9.04 ± 0.68

14.25 ± 3.28

7.68 ± 3.01

0.17 ± 0.00

87.65 ± 26.65

8

1800.70 ± 154.66

2142.54 ± 167.73

2.88 ± 0.15

4.31 ± 0.67

2.70 ± 0.54

1.67 ± 0.29

432.72 ± 53.10

9

1090.97 ± 109.82

2548.08 ± 277.22

8.96 ± 0.40

10.52 ± 4.72

9.65 ± 4.91

1.83 ± 0.29

269.68 ± 24.01

10

369.68 ± 155.83

374.65 ± 153.08

2.54 ± 1.12

3.13 ± 1.66

1.64 ± 0.52

1.33 ± 0.58

192.33 ± 31.98

11

691.13 ± 93.26

1638.89 ± 155.01

11.02 ± 0.99

14.16 ± 8.89

9.16 ± 2.09

1.67 ± 0.29

133.90 ± 31.78

12

441.56 ± 59.51

480.47 ± 71.86

2.45 ± 0.19

3.10 ± 0.33

1.79 ± 0.20

1.00 ± 0.43

186.20 ± 19.02

13

3803.21 ± 170.75

5627.52 ± 2430.69

8.04 ± 0.88

39.04 ± 46.48

38.76 ± 53.16

8.00 ± 0.00

619.12 ± 84.57

14

143.85 ± 16.54

205.76 ± 58.66

6.67 ± 1.42

17.02 ± 8.17

12.11 ± 9.32

2.00 ± 0.00

67.74 ± 27.55

15

74.29 ± 17.48

81.11 ± 19.35

2.21 ± 0.48

3.05 ± 1.01

1.20 ± 0.74

1.42 ± 0.63

47.74 ± 5.92

16

177.10 ± 17.10

250.82 ± 97.56

8.68 ± 1.17

20.144 ± 5.01

12.64 ± 12.72

2.00 ± 0.00

31.45 ± 6.94

17

160.80 ± 12.69

178.64 ± 14.30

7.30 ± 0.38

9.82 ± 0.45

5.98 ± 0.40

3.33 ± 2.31

19.20 ± 2.48

18

74.65 ± 8.31

193.63 ± 27.92

9.85 ± 0.85

48.18 ± 39.82

33.59 ± 27.13

1.83 ± 0.29

10.19 ± 0.58

19

248.66 ± 65.48

251.96 ± 62.45

2.44 ± 0.12

2.55 ± 0.21

1.10 ± 0.47

2.00 ± 0.00

169.08 ± 73.48