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Table 1 Basic study characteristics

From: Direct and indirect therapeutic effect of traditional Chinese medicine as an add-on for non-proliferative diabetic retinopathy: a systematic review and meta-analysis

Study Intervention duration Main indicators Combined treatment Group Number (Number of eyes) Gender
M/F
Age DR staging (I/II/III) Drug (dose) Case exfoliation
JJ, 2018 [26] 12 w Visual acuity, fundus, blood sugar, blood lipid, inflammatory index Hypoglycemia, hypotension, lipid regulation WM + TCM 30 14/16 58.97 CD (500 mg, tid) + Yangyin Xiaoyu Mingmu Prescription(100 ml, bid)
WM 30 15/15 59.2 CD (500 mg, tid)
LWJ, 2015 [23] 9 m Visual acuity, symptom score WM + TCM 38 32/44 57.4 ± 2.8 CD (2 pills, tid) + Qihuang Mingmu Capsule (4 pills, tid)
WM 38    CD (2 pills, tid)
SHL, 2014 [17] 3 m Visual acuity, fundus, blood sugar, blood pressure, blood lipids Control of blood sugar WM + TCM 43 (86) 22/21 50.22 ± 14.82 CD (2 pills, tid) + Qiming Granule(4.5 g, tid)
WM 43 (86) 23/20 50.53 ± 11.28 CD (2 pills, tid)
WQ, 2018 [22] 3 m Clinical efficacy WM + TCM 44 18/26 58.4 ± 7.5 CD (0.5 g,tid) + Qiming Granule (4.5 g, tid)
WM 44 22/22 57.8 ± 6.2 CD (0.5 g, tid)
YXD, 2018 [31] 3 m Visual acuity, mydriasis fundus, anterior segment examination, blood sugar, blood lipid Exercise diet therapy, hypoglycemia WM + TCM 50 24/26 54.63 ± 5.28 19/16/15 CD (0.5 g, tid) + Qiming Granule (1 bag, tid)
WM 46 25/21 55.27 ± 5.42 18/13/15 CD (0.5 g, tid)
HCL, 2018 [29] 12 w Fundus score, blood sugar, blood lipid Diet and exercise, hypotension, lipid regulation WM + TCM 40 (79) 58.95 ± 11.13 18/15/7 CD (0.5 g, tid) + Tangzhiping Prescription (0.5 agents, bid) 3
WM 40 (78) 58.40 ± 9.21 17/17/6 CD (0.5 g, tid) 2
JHZ, 2014 [19] 6 m Clinical symptoms, visual acuity, fundus, optical coherence tomography, hemorheology Standard diet to control blood sugar WM + TCM 51 31/20 57.8 ± 5.7 CD (0.5 g, tid) + Ziyin Yiqi Tongluo Recipe (100 ml, bid)
WM 51 29/22 58.4 ± 6.3 CD (0.5 g,tid)
HXD, 2017 [20] 3 m Clinical efficacy, depression of lesion improvement score, visual acuity, TCM symptom score WM + TCM 40 23/17 52.35 ± 3.11 10/20/10 CD (0.5 g, tid) + Mimeng Flower decoction (0.5 agents, bid)
WM 40 24/16 52.31 ± 3.07 8/22/10 CD (0.5 g, tid)
LD, 2018 [30] 3 m Ophthalmic artery, Central retinal artery, Hypoxia-inducible factor-1α、Stromal cell-derived factor 1 Hypoglycemic drugs, diet and exercise WM + TCM 45 27/16 48.34 ± 6.49 21/13/11 CD (250–500 mg, tid) + Compound Xueshuantong Capsule (3 pills, tid)
WM 45 25/20 48.56 ± 7.64 20/15/10 CD (250–500 mg, tid)
XLP, 2016 [21] 6 m Visual acuity, slit lamp, intraocular pressure, fundus fluorescein angiography Hypoglycemia, hypotension, lipid regulation WM + TCM 110 (216) 69/41 49.5 ± 5.9 - CD (250–500 mg, tid) + Compound Xueshuantong Capsule (3 pills, tid)
WM 110 (214) 68/42 50.2 ± 6.4 CD (250–500 mg, tid)
PCS, 2013 [25] 3 m Fluorescein fundus angiography, hemorheology, visual field agent flash electroretinogram, overall efficacy Basic treatment of diabetes mellitus WM + TCM 28 (56) 12/16 51.7 ± 10.9 14/22/20 CD (500 mg, bid) + Liangxue Sanyu Decoction (0.5 agents, bid) 7
WM 28(56) 13/15 49.3 ± 8.9 13/26/17 CD (500 mg, bid)
LHY, 2019 [16] 3 m Clinical efficacy, visual acuity WM + TCM 60 (60) 34/26 49.4 ± 7.8 34/18/8 CD (1 pill, tid) + Compound Xueshuantong Capsule (3 pills, tid)
WM 60 (60) 32/28 50.3 ± 7.4 34/16/10 CD (1 pill, tid)
CR, 2011 [18] 3 m Clinical efficacy Diabetic diet, hypoglycemic drugs WM + TCM 30 23/7 50.13 ± 6.74 11/7/12 CD (500 mg, tid) + Yiqi Yangyin Huoxue Prescription (100 ml, tid)
WM 30 21/9 51.57 ± 5.62 13/12/5 CD (500 mg, tid)
JCX, 2009 [27] 5 m-1y Fundus examination, visual acuity Hypoglycemia, hypotension and lipid regulation WM + TCM 20 8/12 41–82 6/10/4 Yinxingdamo injection (20 ml, Intravenous drip) + Liuwei Dihuang Decoction
WM 20 7/13 45–79 5/12/3 Yinxingdamo injection (20 ml, Intravenous drip)
ZSZ, 2011 [24] 4 m Clinical efficacy Hypoglycemia, lipid regulation, hypotension WM + TCM 20 (38) 18/22 49.35 - CD (500 mg, tid) + TangWangLing (0.5 agents, bid)
WM 20 (40)     CD 500 mg, tid
YYK, 2016 [28] 3 m Blood sugar, vision, fundus hemorrhage, exudation, microangioma Hypoglycemia, lipid regulation, hypotension WM + TCM 40 22/18 59.85 ± 11.00 15/28/11 CD (0.5 g, tid) + Panax Notoginseng Powder (2 g, tid) -
WM 40 19/21 63.83 ± 9.44 12/30/8 CD (0.5 g, tid)
WZZ, 2017 [32] 3 m Average visual field sensitivity, related cytokines, efficacy, safety indicators Scientific Dietary Exercise WM + TCM 47 (47) 26/21 54.3 ± 4.9 14/18/15 CD (0.5 g, tid) + Qiming Granule (4.5 g, tid) NA
WM 47 (47) 29/18 54.5 ± 4.8 14/18/15 CD (0.5 g, tid)
MJP, 2018 [33] 5 m Clinical efficacy, blood sugar, inflammatory factors Symptomatic treatment WM + TCM 27 (34) 16/11 53.02 ± 4.13 9/10/8 CD (3 pills, tid) + Compound Xueshuantong capsule (3 pills, tid)
WM 27 (34) 15/12 53.08 ± 4.25 10/9/8 CD (3 pills, tid)
  1. Intervention duration, m: month, w: week; gender M/F, M: male, F: female