Fig. 1
From: Effects of alkaloids on peripheral neuropathic pain: a review
The main pharmacological mechanisms of alkaloids on treating DPN. Alkaloids alleviate DPN via inhibiting Nav channels-mediated ectopic discharge in afferent nerve fibers, suppressing purinergic signals in SGC and DRG neurons, and decreasing P38- and NF-κB-mediated peripheral neuroinflammation in DRG