Fig. 2

The TFEB activators from natural products. Phosphorylated TFEB binds to the 14-3-3 protein, which sequesters it in the cytoplasm. Some active ingredients of TCM can dephosphorylate TFEB and translocate TFEB to the nucleus via multiple mechanisms. PKC protein kinase C, TFEB transcription factor EB, mTOR Mammalian (or Mechanistic) target of rapamycin, PGC-1α peroxisome proliferator-activated receptor-γ coactivator 1α, NF-YA nuclear factor-YA