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Table 4 Results of integrating pathway analysis with MetaboAnalyst 4.0

From: Metabolomics coupled with integrated approaches reveal the therapeutic effects of higenamine combined with [6]-gingerol on doxorubicin-induced chronic heart failure in rats

No Pathway Name Match status p − log(p) Impact
1 Glycerophospholipid metabolism 3/36 0.00064401 7.3478 0.21631
2 Biosynthesis of unsaturated fatty acids 2/36 0.014161 4.2573 0
3 Fatty acid degradation 2/39 0.016523 4.103 0.12404
4 Linoleic acid metabolism 1/5 0.026263 3.6396 0
5 Alpha-Linolenic acid metabolism 1/13 0.067028 2.7026 0
6 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1/14 0.072017 2.6308 0.00399
7 Pantothenate and CoA biosynthesis 1/19 0.096614 2.337 0.175
8 Citrate cycle (TCA cycle) 1/20 0.10146 2.288 0.08764
9 Pyruvate metabolism 1/22 0.1111 2.1973 0
10 Arachidonic acid metabolism 1/36 0.17603 1.7371 0
11 Fatty acid elongation 1/39 0.18939 1.6639 0
12 Fatty acid biosynthesis 1/47 0.2241 1.4957 0.01472