Table 3 Pharmacological activities of patchouli on peptic ulcer
From: Pharmacological activities and mechanisms of action of Pogostemon cablin Benth: a review
Chemical name | Animals & pathological model | Efficient doses & administration route | Mechanisms | References |
|---|---|---|---|---|
Pogostone | SD Rats; Indomethacin-induced gastric ulcer | 10, 20 and 40 mg/kg, oral administration | SOD↑, GSH↑, CAT↑, PGE2↑, COX-1↑, COX-2↑, HSP-70↑, Bcl-2↑, MDA↓, Bax↓ | |
PAO | SD Rats; Ethanol-induced gastric ulcer | 10, 20 and 40 mg/kg, oral administration | GSH↑, SOD↑, CAT↑, IL-10↑, MDA↓, caspase-3↓, Fas↓, Fasl ↓, TNF-α↓, IL-1β↓ | [50] |
β-PAE | SD Rats, Ethanol-induced gastric injury | 10, 20 and 40 mg/kg, oral administration | SOD↑, GSH↑, CAT ↑ MDA↓, TNF-α↓, IL-1β↓, IL-6↓, Fas↓, FasL↓, caspase-3 ↓ | [51] |
PO | SD Rats; 2,4,6-trinitrobenzenesulfonic acid-induced IBD | 270 mg/kg, rectal instillation | MPO↓ | [56] |
PA | BalB/C mice; dextran sulfate sodium-induced colitis | 10, 20 and 40 mg/kg, oral administration | MPO↓, TNF-α↓, IFN-γ↓, IL-1β↓, IL-6↓, IL-4↓, IL-10↓, ZO-1, ZO-2↑, claudin-1↑, occludin↑, mucin-1↑, mucin-2↑, Bax↓, Bcl-2↑, RIP3↓, MLKL↓, IDO-1↓, TPH-1↓, | [57] |
C57BL/6 mice; dextran sulphate sodium-induced colitis | 6.25, 12.5 and 25 mg/kg, oral administration | CYP3A4↑, PXR ↑ NF-κB↓, IL-1β↓, IL-6↓, IL-10↓, TNF-α ↓ | [48] |