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Table 3 Pharmacological activities of patchouli on peptic ulcer

From: Pharmacological activities and mechanisms of action of Pogostemon cablin Benth: a review

Chemical name Animals & pathological model Efficient doses & administration route Mechanisms References
Pogostone SD Rats; Indomethacin-induced gastric ulcer 10, 20 and 40 mg/kg, oral administration SOD↑, GSH↑, CAT↑, PGE2↑, COX-1↑, COX-2↑, HSP-70↑, Bcl-2↑, MDA↓, Bax↓ [48, 49]
PAO SD Rats; Ethanol-induced gastric ulcer 10, 20 and 40 mg/kg, oral administration GSH↑, SOD↑, CAT↑, IL-10↑, MDA↓, caspase-3↓, Fas↓, Fasl ↓, TNF-α↓, IL-1β↓ [50]
β-PAE SD Rats, Ethanol-induced gastric injury 10, 20 and 40 mg/kg, oral administration SOD↑, GSH↑, CAT ↑
MDA↓, TNF-α↓, IL-1β↓, IL-6↓, Fas↓, FasL↓, caspase-3 ↓
[51]
PO SD Rats; 2,4,6-trinitrobenzenesulfonic acid-induced IBD 270 mg/kg, rectal instillation MPO↓ [56]
PA BalB/C mice; dextran sulfate sodium-induced colitis 10, 20 and 40 mg/kg, oral administration MPO↓, TNF-α↓, IFN-γ↓, IL-1β↓, IL-6↓, IL-4↓, IL-10↓, ZO-1, ZO-2↑, claudin-1↑, occludin↑, mucin-1↑, mucin-2↑, Bax↓, Bcl-2↑, RIP3↓, MLKL↓, IDO-1↓, TPH-1↓, [57]
C57BL/6 mice; dextran sulphate sodium-induced colitis 6.25, 12.5 and 25 mg/kg, oral administration CYP3A4↑, PXR ↑ NF-κB↓, IL-1β↓, IL-6↓, IL-10↓, TNF-α ↓ [48]
  1. Arrow up denotes activation; arrow down denotes suppression