Fig. 3

Pathway enrichment analyses of the Zheng-specific genes and the targets of the Zheng-specific miRNAs identified in the different case populations. a Bubble diagrams showing the enriched KEGG pathways of PDHS-specific genes (left) and PQDS-specific genes (right) in leukocytes. b Heatmaps indicating the KEGG pathway enrichment results of the validated targets of PDHS-specific miRNAs (left) and PQDS-specific miRNAs (right) in leukocytes. The common pathway terms were specially shown in bold font. c Heatmaps displaying the enriched KEGG pathways of the validated targets of PDHS-specific miRNAs (left) and PQDS-specific miRNAs (right) in serums. The common pathway terms were specially shown in bold font. The pink highlighted pathway terms indicate the commonly enriched pathways of the validated targets of the PDHS-miRNAs in leukocytes and serums. The indigo highlighted pathway terms mark the commonly enriched pathways of the validated targets of the PQDS-miRNAs in leukocytes and serums. PQDS chronic atrophic gastritis patients with Pi-qi-deficiency syndrome, PDHS chronic atrophic gastritis patients with Pi-wei damp-heat syndrome