Fig. 6

Function and pathway analyses of the validated targets of the exosome-carried hsa-miR-122-5p. a Boxplot graphs of expression levels of hsa-miR-122-5p in the leukocytes and serums from different populations. b Overview of the interaction network of targets of hsa-miR-122-5p. The invalidated targets of has-miR-122-5p were retrieved from the released “TarBase” collecting the experimentally supported miRNA-gene interactions, both in vivo and in vitro. Especially, the orange nodes show the validated targets that are also found in the PQDS-specific genes identified in the leukocytes, including JAG2, SH3RF1, MYOF, PCSK6 and COL4A2. c The relationship network of the enriched pathways of targets of hsa-miR-122-5p. A node labeled with a pathway term, indicates an enriched pathway of targets, and the node size depends on the number of edges linking the node. The edge between two nodes denotes that there exist several common genes involved in the two nodes-labeled pathways, so the edge thickness relies on the number of the existed common genes. d The bubble diagram generated to show the enriched pathways of the validated targets of hsa-miR-122-5p. TPM transcripts per million reads, Control healthy individuals, PQDS chronic atrophic gastritis patients with Pi-qi-deficiency syndrome, PDHS chronic atrophic gastritis patients with Pi-wei damp-heat syndrome