Fig. 7

Effects of QSG on the uncoupling of glycolysis from glucose oxidation in HF rats after AMI. a Lactate level in serum and myocardial tissue. Lactate level in serum and myocardial tissue was significantly increased following HF and downregulated with QSG treatment. n = 8 per group. Values are mean ± SE. Asterisks indicates significant differences. *P < 0.05, **P < 0.01. b Myocardial protein expressional levels of LDHA and PDK4 in the three groups. LDHA involved in regulating glycolysis was observably elevated in the model group. LDHA level was significantly down-regulated by treatment of QSG compared with the model group. PDK4, decreasing glucose oxidation by an inhibitory phosphorylation of the pyruvate dehydrogenase complex, was up-regulated in the model group and down-regulated in the QSG group. n = 4 per group. Values are mean ± SE. Asterisks indicates significant differences. *P < 0.05, **P < 0.01