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Table 3 Main GO pathways significantly relating to major hubs

From: Network pharmacology based research into the effect and mechanism of Yinchenhao Decoction against Cholangiocarcinoma

Term Pathway Count Pop hits P Value
GO:0045944 Positive regulation of transcription from RNA polymerase II promoter 32 981 9.79E−16
GO:0043066 Negative regulation of apoptotic process 25 455 4.13E−17
GO:0045893 Positive regulation of transcription, DNA-templated 24 515 8.12E−15
GO:0007165 Signal transduction 21 1161 6.17E−06
GO:0010628 Positive regulation of gene expression 18 262 9.90E−14
GO:0042493 Response to drug 17 304 1.37E−11
GO:0006915 Apoptotic process 17 567 1.08E−07
GO:0006954 Inflammatory response 16 379 3.26E−09
GO:0000122 Negative regulation of transcription from RNA polymerase II promoter 16 720 1.19E−05
GO:0008285 Negative regulation of cell proliferation 15 396 4.72E−08
GO:0032355 Response to estradiol 14 91 3.49E−15
GO:0008284 Positive regulation of cell proliferation 14 466 2.15E−06
GO:0071456 Cellular response to hypoxia 13 96 2.22E−13
GO:0001525 Angiogenesis 13 223 4.64E−09
GO:0006468 Protein phosphorylation 13 456 9.88E−06
GO:0045892 Negative regulation of transcription, DNA-templated 13 499 2.42E−05
GO:0001666 Response to hypoxia 12 172 3.51E−09
GO:0006974 Cellular response to DNA damage stimulus 12 208 2.54E−08
GO:0000165 MAPK cascade 12 262 2.66E−07
GO:0008283 Cell proliferation 12 366 6.90E−06