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Fig. 4 | Chinese Medicine

Fig. 4

From: Cerebralcare Granule® enhances memantine hydrochloride efficacy in APP/PS1 mice by ameliorating amyloid pathology and cognitive functions

Fig. 4

CG enhanced the effects of Mm on reducing Aβ plaque deposition In the hippocampus. a Immunofluorescence for Aβ in the hippocampus of the APP/PS1 mice. Scale bar = 100 μm. b Mean fluorescence intensity of Aβ plaques. c The protein levels of SYN, PSD95, GAP43, APPβ, APPα, APP, and BACE1 were measured by Western blotting in the hippocampus of the different groups (n = 10). dj Quantitative analysis of SYN, PSD95, GAP43, APPβ, APPα, APP, and BACE1 expression, respectively. ^ P < 0.05, ^^ P < 0.01, ^^^ P < 0.01 vs. WT group; * P < 0.05, ** P < 0.01, *** P < 0.01 vs. Tg group; # P < 0.05, ## P < 0.001, ### P < 0.001, vs. Mm group, & P < 0.05, && P < 0.001, &&& P < 0.001, vs. CG group (n = 10)

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