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Fig. 8 | Chinese Medicine

Fig. 8

From: Tanshinone I exerts cardiovascular protective effects in vivo and in vitro through inhibiting necroptosis via Akt/Nrf2 signaling pathway

Fig. 8

TI pretreatment lightened myocardial necroptosis to improve MI/R injury by RIP1/RIP3/MLKL pathway. After ischemia for 30 min and reperfusion for 2 h, hearts were collected, homogenized. The supernatant was collected to detect the related necroptosis proteins (a). The protein expressions of a, b p-RIP1/RIP1, a, c p-RIP3/RIP3, a, d p-MLKL/MLKL were evaluated by western blotting. Value represents mean ± SD (n = 5), **p < 0.01, ***p < 0.001 vs. MI/R group

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Chinese Medicine

ISSN: 1749-8546

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