Fig. 3

Effects of CSBTA on PIPN-induced pro-inflammatory cytokines release and gene expression in serum and tissues of rats. The release of IL-1β (left), PGE2 (middle), and TNF-α (right) in serum (A) and plantar skin supernatant (B) (n = 6). C The gene expression of pro-inflammatory cytokines in the spinal cord (C) and DRG (D) (n = 8). ##p < 0.01, #p < 0.05 compared with the blank groups; *p < 0.05, **p < 0.01 compared with paclitaxel group