Skip to main content

Table 2 Herbal bioactive compounds exert an effect ongut mircrobiota

From: Herbal therapy for ameliorating nonalcoholic fatty liver disease via rebuilding the intestinal microecology

Chinese herbal formulas Model Regulatory effects on the microbiota Key mechanisms Ref
Resveratrol Mice Ecoli and Streptococcus↓, Lactobacilli and Bifidobacterium↑ Improving the gut microbiota dysbiosis and lowering both body and visceral adipose weights [49]
Puerariae radix Mice PRE mediated preservation of gut barrier integrity is involved in restoring ZO-1 Decreasing intestinal permeability [61]
Ferulic acid Mice The ratio of Firmicutes to Bacteroidetes and the proportions of Firmicutes↓, the proportions of Bacteroidetes Altering the composition of gut microbiota [72]
Pu-er tea extract Mice Bacillus, Streptococcus and Lactococcus genera ↓ Reducing inflammation, significant reducting in fatty infiltration [66]
Curcumin Rats Clostridium, Bacteroides, Citrobacter, Cronobacter, Enterobacter, Enterococcus, Klebsiella, Parabacteroides, and Pseudomonas↑, Blautia and Ruminococcus↓ Ameliorating hepatic steatosis by downregulating expression of MLCK in the intestinal mucosa of rats with NAFLD, improving TJ structure of the intestinal mucosa [67,68,69]
Diosgenin Rats Lactobacillus murinus and Lactobacillus reuteri↑ Preventing the developmentof NAFLD through the AMPK and LXR signaling pathways [85]
Berberine Humans Lactobacteriaceae↑, Enterobacteriaceae Improving hepatic lipid metabolism [99]
Gynostemma pentaphyllac Mice Eubacterium, Blautia, Clostridium and Lactobacillus Modulating he gut microbiota and suppressing hepatic miR-34a [107]
Radix Polygoni Multiflori Rats The content of short-chain FA produced by gut microbial fermentationc Reliving high contents of TG, TC in liver tissue and LPS level in portal venous [111]
Quercetin Mice Firmicutes/Bacteroidetes ratio↑ Alleviation of intestinal microbiota dysbiosis, related “Gut-Liver Axis” activation [40]
MP-A Rats Remodellig gut microbiota structure Inhibiting the LPS-TLR4-NF-κB pathway activation, suppress PPAR γ and SREBP-1c expression [95]
Green Tea Extract Mice Induced changes in the composition of the gut microbiota mRNA expression levels of lipogenic and inflammatory genes were downregulated [124]
Silymarin   Blautia, Akkermansia, Bacteroides Attenuating hepatic steatosis [83]
Rhizoma Coptidis Mice Sporobacter termitidis, Alcaligenes faecalis, Akkermansia muciniphila↑, Escherichia coli, Desulfovibrio C21_c20, Parabacteroides distasonis Regulating lipid homeosta-sis by modulation gut microbiota and hepatic lipid metabolism [86]