Fig. 8

Network analysis. a Protein–protein interaction network analysis. The thickness of the line reflects the magnitude of Betweenness Centrality, and the color and depth of the nodes (blue → yellow → red) represent the size of the degree value (high → low). b Compound-Target network analysis. The navy-blue squares represent the compounds, and diverse colors of circles represent the target proteins distributed in various areas of the cell, such as extracellular region, plasma membrane, cytosol, endoplasmic reticulum, mitochondrion, and nucleus. c Target-Pathway network analysis. The navy-blue squares represent the pathways which were the top 15 significant changes in KEGG enrichment