Fig. 4

Binding sites of the crystal structure of MCR-1 (5GRR) with active compounds of Pingwei Pill. A is the surface binding between 5GRR and compounds. B is cartoon binding graph, and the left panel is the overall view, the right panel is the focused view (the 5GRR protein is gray, the binding site is gray-blue, and compounds is heavy yellow). The gray dashed line represents a hydrophobic interaction, the blue solid line represents a hydrogen bond, and the green dashed line represents π-stacking