Table 1 Selcect Aloin targets and network topology parameter
From: Aloin induced apoptosis by enhancing autophagic flux through the PI3K/AKT axis in osteosarcoma
Gene | Degree | Betweenness | Closeness |
|---|---|---|---|
ALB | 94 | 0.22467212 | 0.64726027 |
AKT1 | 82 | 0.10659732 | 0.61967213 |
EGFR | 65 | 0.05548461 | 0.57446809 |
SRC | 59 | 0.04756542 | 0.55752212 |
CASP3 | 57 | 0.04143446 | 0.5625 |
HSP90AA1 | 57 | 0.05023598 | 0.55588235 |
MAPK8 | 52 | 0.02459074 | 0.53846154 |
ESR1 | 52 | 0.03272838 | 0.53846154 |
RHOA | 42 | 0.02871204 | 0.51780822 |
MAPK14 | 39 | 0.02442919 | 0.50670241 |
NOS3 | 38 | 0.02906078 | 0.52793296 |
ANXA5 | 36 | 0.00644395 | 0.50534759 |
AR | 36 | 0.01980948 | 0.504 |
KDR | 31 | 0.00735314 | 0.49606299 |
IGF1R | 28 | 0.00777869 | 0.4871134 |
PGR | 28 | 0.00682124 | 0.48586118 |
JAK2 | 26 | 0.00395944 | 0.48337596 |
XIAP | 26 | 0.00384509 | 0.47848101 |
DHFR | 26 | 0.03720463 | 0.48963731 |
SERPINA1 | 26 | 0.02045756 | 0.48461538 |
F2 | 25 | 0.0220183 | 0.47487437 |
NOS2 | 25 | 0.02107948 | 0.48963731 |
LCK | 24 | 0.00374638 | 0.47848101 |
PRKACA | 24 | 0.01605781 | 0.45215311 |
PARP1 | 24 | 0.00296672 | 0.47607053 |
HSPA8 | 24 | 0.00657807 | 0.48461538 |
SOD2 | 24 | 0.01434656 | 0.48461538 |
PTPN1 | 23 | 0.00625243 | 0.47848101 |
TYMS | 23 | 0.02290566 | 0.46210269 |
CCL5 | 23 | 0.02444585 | 0.46782178 |
AKR1B1 | 23 | 0.01604294 | 0.4871134 |
REN | 23 | 0.01096858 | 0.48091603 |
CTSD | 23 | 0.01401781 | 0.4871134 |
CTSB | 22 | 0.00521861 | 0.4713217 |
PPARG | 22 | 0.01297883 | 0.47848101 |
GSK3B | 22 | 0.0135452 | 0.47607053 |
MMP3 | 22 | 0.00435397 | 0.46898263 |
CDK2 | 22 | 0.00497381 | 0.47969543 |
CCNA2 | 21 | 0.00303664 | 0.47487437 |
ESR2 | 20 | 0.00923214 | 0.47368421 |
NQO1 | 20 | 0.01513652 | 0.48337596 |
LDHB | 20 | 0.02011272 | 0.41906874 |
PLAU | 20 | 0.01704925 | 0.46666667 |
APRT | 20 | 0.01825685 | 0.41906874 |
HK1 | 20 | 0.01457167 | 0.47969543 |
CDK6 | 19 | 0.00306573 | 0.4375 |
GSR | 19 | 0.00645307 | 0.48461538 |
GSTP1 | 19 | 0.018327 | 0.47368421 |
CHEK1 | 19 | 0.00214974 | 0.44575472 |
KIT | 18 | 0.01193652 | 0.46323529 |
ADAM17 | 18 | 0.0033682 | 0.45985401 |
BACE1 | 17 | 0.00213241 | 0.45873786 |
MMP13 | 17 | 0.0012115 | 0.45873786 |
CASP7 | 17 | 7.17E−04 | 0.45985401 |
AURKA | 17 | 0.00146614 | 0.4375 |
MMP7 | 17 | 8.03E−04 | 0.45873786 |
CTSG | 16 | 0.00426012 | 0.43851508 |
MAPK10 | 16 | 0.01109269 | 0.45762712 |
TTR | 15 | 0.00498248 | 0.43648961 |
CTSK | 15 | 0.00240011 | 0.42857143 |
FGFR1 | 15 | 0.00103615 | 0.45 |
PGF | 15 | 0.00283624 | 0.45542169 |
MMP8 | 15 | 0.0060175 | 0.45985401 |
SELP | 15 | 0.00529684 | 0.45432692 |
CTNNA1 | 15 | 0.00111691 | 0.41629956 |
GC | 14 | 0.00248048 | 0.43052392 |
RXRA | 14 | 0.00553557 | 0.44893112 |
TGFBR1 | 13 | 0.00140318 | 0.44893112 |
RAC2 | 13 | 0.00111334 | 0.42281879 |
PDPK1 | 13 | 4.16E−04 | 0.43150685 |
FKBP1A | 13 | 0.00421252 | 0.43249428 |
CDA | 13 | 0.00590545 | 0.37724551 |
PCK1 | 13 | 0.00718678 | 0.45 |
RHEB | 12 | 0.00261494 | 0.43052392 |
PNP | 12 | 0.00616886 | 0.375 |
SULT2A1 | 12 | 0.00444855 | 0.43953488 |
LYZ | 12 | 0.00507557 | 0.42954545 |
AKR1C3 | 12 | 0.00267438 | 0.39130435 |
EPHA2 | 11 | 0.00216285 | 0.421875 |
PAH | 11 | 0.00349199 | 0.44158879 |
AHCY | 11 | 0.00463874 | 0.40997831 |
RAB11A | 11 | 0.01089449 | 0.44893112 |
RAB5A | 11 | 3.99E−04 | 0.44158879 |
PDE5A | 11 | 0.00318536 | 0.44055944 |
TYMP | 11 | 0.00444257 | 0.42567568 |
NR1I2 | 11 | 0.00561541 | 0.44680851 |
F7 | 11 | 0.0018532 | 0.42281879 |
SYK | 11 | 0.00397399 | 0.43249428 |
ERBB4 | 11 | 1.90E−04 | 0.42 |
HMGCR | 11 | 0.00974638 | 0.4478673 |
HSD17B1 | 10 | 0.00143199 | 0.37649402 |
OTC | 10 | 0.01325372 | 0.421875 |
PPIA | 10 | 0.00163724 | 0.45432692 |
PIM1 | 10 | 0.01355121 | 0.43448276 |
CSNK2A1 | 10 | 0.00106061 | 0.41814159 |
SORD | 10 | 0.00381009 | 0.43851508 |