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Table 2 Disease clusters enriched with differential proteins of the two Syndromes

From: Exploring biological basis of Syndrome differentiation in coronary heart disease patients with two distinct Syndromes by integrated multi-omics and network pharmacology strategy

Syndrome

Enrichment score/Rank

Disease term

#Mapped genes

Total genes

Percentage

P

CCQS

3.69/1

Myocardial infarct

5

121

20.83%

2.51E−05

  

Coronary Artery Disease|

4

52

16.67%

5.63E−05

 

3.39/2

Coronary Disease|Coronary heart disease|

Inflammation|Insulin Resistance

5

59

20.83%

1.42E−06

  

Atherosclerosis, coronary

5

155

20.83%

6.61E−05

  

Cardiovascular disease

4

59

16.67%

8.23E−05

  

Metabolic syndrome

4

165

16.67%

0.00168

  

Obesity

5

369

20.83%

0.00177

  

Cardiovascular Diseases

4

189

16.67%

0.00248

  

Diabetes, type 2

5

439

20.83%

0.00334

QSBS

5.26/1

Myocardial ischemia

5

18

21.74%

7.85E−09

  

Carotid atherosclerosis

5

21

21.74%

1.53E−08

  

Atherosclerosis, coronary

6

155

26.09%

1.73E−06

  

Recurrence|Venous Thromboembolism

4

58

17.39%

6.60E−05

  

Brain Ischemia|Hypertension|Osteoporosis|Stroke

4

64

17.39%

8.87E−05

  

Cardiovascular Diseases

4

67

17.39%

1.02E−04

  

Alzheimer's disease

5

950

21.74%

0.03828