Fig. 2

BHD restores renal function and alleviates kidney injury in STZ-induced diabetic mice. A Periodic acid Schiff (PAS) staining and score. Mesangial matrix expansion in glomeruli and the thickening of the glomerular basement membrane were observed. Scale bar: 50 µm. B Microalbuminuria, and C Blood glucose levels in diabetic mice over 16 weeks. DM, diabetes mellitus. Irbesartan (IRB) was taken as a positive control. Data represent the means  ±  SEM for groups of six animals. *P  <  0.05, **P  <  0.01, ***P  <  0.001 versus normal mice. ^#P  <  0.05, ^##P  <  0.01, ^###P  <  0.001 versus DM mice