Fig. 3From: Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugsPossible mechanism of Immune idiosyncratic DILI. Drugs or their metabolic products combine with liver specific proteins to become antigens, which can be phagocytosed by phagocytes and expressed on the cell surface. They can be recognized by CD4+ cells, stimulate the production of cytokines, activate the CD8+T cells of effector cells, and produce cytotoxicity leading to liver damageBack to article page