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Table 3 Compounds identified in four Kadsura species using UPLC-Q/TOF–MS/MS

From: Comparison of blood tonic efficacy and chemical constituents of Kadsura interior A.C. Smith and its closely related species

No. Compounds Rt (min) Fomula Error (× 10–6) Measured [M + H] +  Major fragments Calculated m/z Structural type KIS KHS KLS KJS
(Measured [M + Na] +)[Measured  [2 M + Na]+]
1* Vanillic Acid 0.96 C8H8O4 − 4.17 169.0494 151.0385, 141,9584 168.0423 phenolic acids Y↓ Y↑ Y Y
2* 7-O-Methylcedrusin 1.35 C20H24O6 − 2.50 361.1642 331.1591, 151.0762 360.1573 phenolics Y Y Y Y
3* ( +)-Pinoresinol 1.98 C20H22O6 4.18 359.1509 342.1393, 323.1288, 313.1444 358.1416 lignans Y↓ Y Y↑ Y
4* Kadsutherin H 3.7 C24H26O9 0 459.1655 399.1460, 371.1475, 339.1221 458.1577 lignans Y / / /
5 Micrandilactone I 4.53 C30H44O7 0.17 517.3161   516.3087 triterpenoids / / Y /
6 Kadsuranin 4.87 C23H28O6 − 1.12 401.1954   400.1886 lignans Y↓ Y Y↑ Y
7* Coumarinlignan 4.89 C20H16O7 − 1.90 369.0967 351.0896, 321.0761, 203.0324 368.0896 lignans Y Y / /
8 Schisantherin G 4.99 C29H34O11 2.34 559.2187   588.2101 lignans / / Y Y
9 Kadoblongifolin B 5.43 C22H24O8 1.92 417.1557 399.1437, 382.3145 416.1471 lignans Y Y Y↑ Y↓
10* Heteroclitin G 5.57 C22H24O7 − 0.75 401.1597 383.1509, 341.1031, 313.1082 400.1522 lignans Y↑ Y Y Y↓
11* Kadsutherin F 5.96 C28H28O8 4.47 493.1884 403.1661, 401.1638,383.1509 492.1784 lignans Y / / /
12* Schisandrol A 6.22 C24H32O7 3.93 (455.2063) 415.2180, 384.1929 432.2148 lignans Y Y Y Y
13 Angeloylgomisin M1 6.28 C27H32O8 4.13 485.2195 401.1617, 385.1644, 371.1505 484.2097 lignans Y↑ Y↓ Y Y
14* Interiorin C 6.35 C24H26O8 4.98 443.1728 383.1509, 355.1547 442.1628 lignans Y↑ Y Y Y
15* Heteroclitin E 6.49 C27H30O9 0.80 499.1972 399.1450, 371.1515, 339.1221 498.189 lignans Y Y Y /
16* Benzoyl Oxokadsuranol 6.64 C29H28O9 − 1.92 521.1801 503.1685, 399.1460, 371.1475 520.1733 lignans Y Y Y Y
17* Schisantherin E 6.96 C30H34O9 − 4.27 (561.2078) 417.1923, 373.1645 538.2203 lignans / / Y /
18 Longipedlignan H 6.97 C24H26O9 − 1.53 459.1648 399.1460, 355.1161, 327.1205 458.1577 lignans Y Y↑ Y↓ Y
19 Longipedlignan E 7.03 C27H32O9 2.26 [1023.4008]   500.2046 lignans / Y / /
20 4β,9β-dihydroxy-1α,5α-H-guaia-6,10 (14)-dien 7.07 C15H24O2 1.69 236.178 219.1757, 194.1159 236.1776 sesquiterpenoids Y Y↑ Y Y↓
21 Acetoxyl Oxokadsurane 7.63 C24H26O8 2.26 443.1688 383.1468, 355.1547 442.16 lignans / / Y /
22 Longipedlactone C 7.66 C30H40O6 3.31 497.2914   496.2825 triterpenoids / Y Y Y
23 Piperitol 7.8 C20H20O6 0 357.1338 311.0954, 222.1118 356.126 lignans Y Y↓ Y↑ Y
24 Kadoblongifolin A, Kadoblongifolin B 8.65 C22H24O8 − 0.48 417.1547 385.1685, 354.2850, 315.0891 416.1471 lignans Y Y Y↓ Y↑
25 Schizanrin M 8.75 C22H24O7 0.50 401.1602 383.1576, 354.2850, 186.0572 400.1522 lignans Y Y Y↑ Y↓
26 6-hydroxyhinokinin 8.85 C20H18O7 3.24 (393.0963) 357.1370, 325.1088 370.1053 lignans Y↓ Y↑ Y Y
27 Interiotherin B 9.01 C27H30O9 0.80 499.1972 399.1437, 382.3145, 355.1175, 325.1088, 279.0919 498.189 lignans Y↑ Y↓ Y Y
28 Angeloylbinankadsurin A 9.21 C27H32O8 − 0.41 485.2186 385.1644, 354.2850 484.211 lignans Y↓ Y Y Y↑
29 Gomisin J 9.67 C22H28O6 − 2.65 389.1948   388.1886 lignans Y Y / Y
30 Kadsulignan I 10.34 C25H28O8 1.32 457.1868 371.1492, 356.1256 456.1784 lignans Y↑ Y↓ Y Y
31 Angeloylgomisin R 10.49 C27H30O8 0 483.2019 383.1492, 368.1260 482.1941 lignans Y↑ Y Y↓ Y
32 Interiorin D 10.92 C29H28O8 − 0.99 505.1861 497.1571 504.1788 lignans Y↑ Y Y↓ Y
33 Heteroclitin O 11.22 C34H32O11 2.84 617.2035   616.1945 lignans / / Y /
34 Longipedlignan I 11.48 C26H30O9 2.41 486.1902n   486.189 lignans Y Y Y Y
35 Schizanrin F 11.51 C32H34O11 1.19 595.2181   594.2101 lignans Y↓ Y Y↑ Y
36 Kadnanolactone A 11.65 C30H38O5 1.25 479.2803 432.2034, 415.1756 478.2719 triterpenoids Y↓ Y↑ Y Y
37 ( +)-Gomisin K3 12.04 C23H30O6 0.62 403.2118   402.2042 lignans Y Y Y Y
38 Heteroclitin C, Heteroclitin B 12.11 C28H34O8 3.38 (521.2163)   498.2254 lignans Y Y↓ Y↑ Y
39 Kadlongilignan E 12.34 C27H30O9 − 0.20 499.1967 483.2374, 399.1437, 369.1348 498.189 lignans / Y↓ Y↑ /
40* Heteroclitin D 12.65 C27H30O8 − 4.77 483.1996 383.1549, 366.1547, 323.1251 482.1941 lignans Y↑ Y Y Y↓
41 Longipedlactone B 13.2 C30H40O5 1.62 481.2956   480.2876 triterpenoids / Y Y Y↑
42 Licarin A 13.36 C20H22O4 − 4.91 327.158 270.3151, 229.1418, 182.9854 326.1518 lignans Y Y Y Y
43* Schisantherin A 13.43 C30H32O9 − 2.05 (559.1933) 415.1763, 371.1475, 340.1289 536.2046 lignans / Y↑ Y↓ Y
44* Schisantherin B 13.45 C28H34O9 1.36 (537.2108) 415.1805, 371.1475 514.2203 lignans / Y Y Y
45* Kadsurin 15.53 C25H30O8 − 4.36 459.1999 400.1850, 369.1675, 354.1414 458.1941 lignans Y / / /
46 Isoanwulignan, ( +)-anwulignan 16.38 C20H24O4 3.00 (351.1577)   328.1675 lignans Y Y Y Y
47 Interiotherin C 16.75 C30H36O10 4.42 (579.2225) 457.1851, 357.1331 556.2308 lignans Y Y Y /
48 Gomisin A (Schisandrol B), Gomisin O 16.84 C23H28O7 3.87 417.1924   416.1835 lignans Y↓ Y↑ Y Y
49 Schiarisanrin D 16.98 C31H30O8 1.13 531.2025 383.1471, 355.1522, 186.0572 530.1941 lignans Y Y Y /
50* D-Epigalbacin 18.16 C20H20O5 − 4.70 341.1373 323.1269, 302.3088, 279.0953 340.1311 lignans / / Y /
51 Schizandrin 18.2 C24H32O7 0 (455.2031) 385.1644, 354.2889, 279.0919 432.2148 lignans / Y / /
52* Gomisin N 20.07 C23H28O6 0.50 401.1966 370.1750, 355.1541 400.1886 lignans Y↑ Y Y Y
53 Schizandrin C 21.25 C22H24O6 3.64 (407.1485) 385.1641, 301.1434 384.1573 lignans / / Y /
54 Heteroclitin A, Caproylbinankadsurin A 22.02 C28H36O8 4.23 (523.2324)   500.241 lignans / Y / /
55* Manwuwezic Acid 26.21 C30H46O4 4.46 471.3495 453.3355 470.3396 triterpenoids Y Y Y Y
56* Prinsepiol 29.77 C20H22O8 2.05 391.1401 371.3170, 284.2935, 279.1594 390.1315 lignans Y Y Y Y
  1. Compounds marked with * were identified with standard compound, other 36 compounds were identified with the in-house database
  2. Y: exist; /: don’t exist; ↑: significantly highest content; ↓: with lowest content