Fig. 7

Immunofluorescence staining of BrdU and NeuN in the DG reveals a dosage-dependent effect of HE treatment on neurogenesis. Scale bar: 100 µm (A). Note, there was a significant increase in BrdU⁺ cells in the DG of CRS animals receiving 10 mg/kg HE, but not 25 mg/kg HE (B). Double labelling of BrdU and NeuN showed deceased neuronal maturation in the CRS + 25 mg/kg HE group (C). **p ≤ 0.01; ***p ≤ 0.001