Fig. 3

Effects of LGZG on hyperglycemia, glucose tolerance and insulin tolerance in HFD-fed mice. a Body weight changes during the LGZG treated period. Weight is measured once a week (n = 9 per group). b Changes in fasting blood glucose levels after a switch to HFD The blood glucose level is measured once a week. c, d Glucose tolerance (c) and insulin tolerance (d) after 9 weeks of LGZG treatment on HFD. For the IPGTT, mice were injected with glucose (2 mg/g body weight) after an 8-h fasting. AUC of the IPGTT (e) and ITT (f). For the ITT, mice were injected with insulin (0.75 U/kg body weight) after a 6-h fasting. The data are expressed as mean ± SD (n = 9). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.001 vs. Mod group