Fig. 2

Signalling pathway of glycolysis in PAH. Cocultivation of PASMCs and HPAECs promotes endothelial regeneration and collagen synthesis through BMPR2-Notch1-mediated glycolysis, resulting in the development of PAH. BMPR2 activated Notch1 via mediating the activation of ILK. Meanwhile, APLN, HMOX1 and NOS3 are MYC targets of transcription, those gene of upregulation induced HPAECs proliferation. PASMCs pulmonary arterial smooth muscle cells, HPAECs human pulmonary arterial endothelial cells, BMPR2 bone morphogenetic protein receptor 2, ILK Integrin-linked kinase, N1ICD Notch1 intracellular domain, PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3