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Fig. 3 | Chinese Medicine

Fig. 3

From: Ginkgo biloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways

Fig. 3

The effect of EGb on the protein expression levels of TGF-β1, smad2/3, p-smad2/3, p-p38MAPK, p38MAPK and the effect of p38 MAPK gene expression in rat kidney tissue. A Representative images (× 400 magnification) of TGF-β1 immunohistochemically stained renal tissue sections. B Quantification of TGF-β1 expression in renal tissues. C Western blot analysis of smad2/3, p-smad2/3, p-p38 MAPK, p38MAPK, TGF-β1 expression in rat kidney tissues. Quantitative analysis the protein levels of D TGF-β1, E, F smad2/3, G, H p-smad2/3, I p-p38MAPK, J p38MAPK, and the ratio of K p-p38MAPK/p38MAPK in renal tissues. L Reverse transcription-quantitative PCR analysis p38 MAPK mRNA expression in rat kidney tissues. n  = 9. *P  < 0.05 vs. control; #P  < 0.05 vs. cisplatin; &P  <  0.05 vs. cisplatin  +  M-EGb. MAPK mitogen-activated protein kinase; p- phosphorylated; TGF-β1 transforming growth factor β1; L low-dose; M medium-dose; H high-dose; EGb Ginkgo biloba leaf extract

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Chinese Medicine

ISSN: 1749-8546

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