Table 2 Comparison of primary outcome between treatment groups
Primary outcome measure | Adjusted mean difference (95% CI)a | Adusted modelb | |||||||
|---|---|---|---|---|---|---|---|---|---|
LPT group | HPT group | WL group | LPT group vs HPT group | LPT group vs WL group | HPT group vs WL group | ||||
Mean difference (95% CI) | P value | Mean difference (95% CI) | P value | Mean difference (95% CI) | P value | ||||
Change from baseline in WOMAC total score (modified intention to treat, n=661)c | |||||||||
 4 weeks | −16.49 (−19.74 to −13.25) | −19.54 (−22.99 to −16.10) | −6.20 (−9.16 to −3.24) | 1.06 (−3.63 to 5.76) | 0.66 | −10.58 (−15.22 to −5.93) |  < 0.001 | −11.64 (−16.31 to −6.98) |  < 0.001 |
 8 weeks | −20.67 (−23.95 to −17.39) | −22.88 (−26.34 to −19.42) | −10.76 (−13.77 to −7.75) | 0.31 (−4.43 to 5.05) | 0.90 | −10.11 (−14.81 to −5.41) |  < 0.001 | −10.42 (−15.13 to −5.71) |  < 0.001 |
 12 weeks | −20.91 (−24.23 to −17.58) | −25.41 (−28.91 to −21.91) | −12.64 (−15.66 to −9.62) | 2.52 (−2.23 to 7.27) | 0.30 | −8.39 (−13.15 to −3.63) |  < 0.001 | −10.91 (−15.67 to −6.15) |  < 0.001 |
 16 weeks | −23.13 (−26.44 to −19.82) | −27.38 (−30.84 to −23.91) | −13.51 (−16.51 to −10.52) | 2.21 (−2.51 to 6.92) | 0.36 | −9.77(−14.47 to −5.07) |  < 0.001 | −11.97(−16.71 to −7.24) |  < 0.001 |
Change from baseline in WOMAC total score (per protocol, n=625)d | |||||||||
 4 weeks | −16.831 (−20.10 to −13.56) | −19.55 (−23.01 to −16.09) | −6.25 (−9.21 to −3.29) | 1.09 (−3.63 to 5.82) | 0.65 | −10.86 (−15.54 to −6.18) |  < 0.001 | −11.96 (−16.62 to −7.30) |  < 0.001 |
 8 weeks | −21.52 (−24.81 to −18.24) | −23.00 (−26.47 to −19.52) | −10.73 (−13.70 to −7.76) | −0.11 (−4.84 to 4.63) | 0.96 | −11.14 (−15.83 to −6.44) |  < 0.001 | −11.03 (−15.71 to −6.36) |  < 0.001 |
 12 weeks | −21.44 (−24.73 to −18.15) | −25.84 (−29.31 to −22.36) | −12.69 (−15.66 to −9.71) | 2.82 (−1.92 to 7.55) | 0.24 | −9.15 (−13.85 to −4.45) |  < 0.001 | −11.97 (−16.65 to −7.29) |  < 0.001 |
16 weeks | −23.89 (−27.16 to -−0.62) | −27.91 (−31.37 to −24.45) | −13.68 (−16.65 to −10.72) | 2.39 (−2.33 to 7.10) | 0.32 | −10.54 (−15.22 to −5.86) |  < 0.001 | −12.93 (−17.59 to −8.27) |  < 0.001 |