Fig. 7
Cognitive impairment induced by Aβ1−42 was mitigated by salidroside in WT mice, but not in Nrf2−/−mice. A Schematic diagram of NORT. B Schematic diagram of Y maze. C OFT results showed no significant difference was observed in the total distance between the Aβ1−42 group and salidroside treatment group in Nrf2−/− mice and WT mice. D There was no preference for the novel object in the Aβ1−42-Nrf2−/− mice after salidroside treatment, whereas those Aβ1−42-WT mice administered with salidroside performed comparable to the WT mice. E Spontaneous alternation (%) showed Aβ1−42 -treated mice decreased alternations while salidroside reversed this impairment in WT mice but not Nrf2−/− mice. F Time in the novel arm (%) was reduced after Aβ1−42 treatment, the decrease after salidroside was reversed in WT mice but not Nrf2−/− mice. *P < 0.05, **P < 0.01, ***P < 0.001, “ns” means no significant difference (P > 0.05)