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Fig. 7 | Chinese Medicine

Fig. 7

From: An anti-inflammatory and anti-fibrotic proprietary Chinese medicine nasal spray designated as Allergic Rhinitis Nose Drops (ARND) with potential to prevent SARS-CoV-2 coronavirus infection by targeting RBD (Delta)- angiotensin converting enzyme 2 (ACE2) binding

Fig. 7

ARND exhibited anti-inflammatory effects. A Viability of RAW264.7 macrophages was unaltered after treatment with 0.625–5 µL/mL ARND for 48 h, suggesting that ARND was devoid of toxicity (n = 5). B–D Treatment with inflammatory M1 inducers (20 ng/mL IFN-γ and 100 ng/mL LPS) was used to establish the inflammatory cell model. The group receiving neither ARND nor inflammatory M1 inducers served as the control group whereas the group treated with only inflammatory M1 inducers served as the model group. The mRNA expression levels of the inflammatory biomarkers, including transcription factors (NFκB2 and c-Rel), cytokines (IL-1β, IL-6, TNF-α and CCL-2) as well as nitric oxide synthase 2 (NOS2) were significantly upregulated in the model group, while cells pre-treated with ARND showed significant downregulation of the mRNA expressions of the inflammatory biomarkers (n = 4). * p < 0.05, **p < 0.01 and ***p < 0.001 vs 0 µL/mL

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Chinese Medicine

ISSN: 1749-8546

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