Fig. 10

The validation of the mechanism of YQHY on the BGC823/5–Fu-CSCs drug resistance using IGF-1. A, B The expression of PI3K, p-PI3K, AKT, p-AKT and Nrf2 proteins after YQHY/YQHY + IGF-1 intervention. C The mRNA expression of MDR1 and MRP1. D The cell viability rates of BGC823/5–Fu-CSCs. E, F The apoptosis rates of BGC823/5–Fu-CSCs. A–E The duration of administration was 48 h