Table 1 The antinociceptive activity of individual curcumin, piperine, and curcumin-piperine combination in the formalin, tail-flick and cold plate tests
|  | ED50 ± SEM | γ | |||
|---|---|---|---|---|---|
Curcumin | Piperine | Combination | |||
Theoretical additive | Experimental | ||||
Formalin Test | 71.4 ± 21.9 | 18.4 ± 3.1 | 44.9 ± 12.5 | 5.9 ± 2.2 *** | 0.13 |
Tail-Flick Test | 34.4 ± 6.1 | 8.1 ± 0.8 | 21.3 ± 3.4 | 5.2 ± 0.6 *** | 0.24 |
Cold Plate Test | 31.9 ± 5.5 | 28.1 ± 6.3 | 30.0 ± 5.9 | 5.5 ± 0.7 | 0.18 |