Identification of potential immunomodulators from Pulsatilla decoction that act on therapeutic targets for ulcerative colitis based on pharmacological activity, absorbed ingredients, and in-silico molecular docking

Table 1 The components of BTWT that bound to five selected protein targets in a similar way as positive-control compounds

BTWT	Components	JAK3	STAT3	S1PR1	PD-1	PD-L1
R. pulsatilla	AB4			√	√	√
	AA3		√	√
	23-HA		√
R. coptidis/ C. phellodendri	Berberine	√				√
	Palmatine	√			√	√
	Jatrorrhizine				√	√
	Coptisine	√				√
	Epiberberine	√			√	√
	Phellodendrine				√	√
C. fraxini	Aesculin	√	√	√		√
C. fraxini	Aesculetin	√

ISSN: 1749-8546