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Table 2 The differential metabolites in lung tissue of mice

From: Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury

NO.

Metabolites

Formula

Rt (min)

M/Z

VIP

Con vs. LPS

LPS vs.DM-M

LPS vs.DM-H

Fragmentations (m/z)

P

FC

P

FC

P

FC

1

Ergothioneine

C9H15N3O2S

0.94

230.0975

6.85519

8.89E-06

5.223586

0.028336

0.722204

0.000399

0.484999

69.0580; 127.0362

2

( +)-Gallocatechin

C15H14O7

1.07

307.0829

5.01184

3.85E-14

1.539765

2.77E-09

0.776547

9.53E-09

0.573716

139.0390; 307.08113

3

Oxidized glutathione

C20H32N6O12S2

1.08

635.142

1.24098

0.001474

1.349826

0.063388

0.857859

1.44E-05

0.603938

355.0759; 484.1187

4

Inosinic acid

C10H13N4O8P

0.97

349.056

3.46688

1.50E-06

2.506744

0.06727

0.82939

1.75E-06

0.426869

97.0298; 137.0457

5

Guanosine monophosphate

C10H14N5O8P

0.95

364.0649

3.05321

0.00017

1.608101

0.084982

0.856493

4.66E-06

0.533426

152.0562

6

S-Adenosylhomocysteine

C14H20N6O5S

1.05

385.1303

2.64985

2.61E-05

1.629015

0.016513

0.811106

0.00022

0.686493

112.0183; 170.0849

7

all-trans-5,6-Epoxyretinoic acid

C20H28O3

13.52

317.2117

2.30797

0.000264

1.933585

0.045855

0.778557

0.000488

0.550082

79.0542; 281.1900

8

Creatine

C4H9N3O2

0.91

132.0775

1.79766

6.98E-05

1.485564

0.002392

0.766444

5.19E-06

0.595529

44.1000; 55.2000

9

LysoPC(17:0/0:0)

C25H52NO7P

18.32

527.3804

1.36725

7.89E-06

3.681324

0.018519

0.721019

0.000698

0.545856

184.0733; 492.3449

10

Pyridoxamine

C8H12N2O2

0.78

191.0781

1.1411

1.63E-06

1.624016

3.72E-06

0.662852

5.36E-07

0.599696

134.0606; 151.0871

11

Spermidine

C7H19N3

0.72

146.1654

1.13866

1.21E-05

1.445056

0.007625

0.818006

2.44E-06

0.659883

72.0820; 84.0840

12

L-Proline

C5H9NO2

0.91

116.0703

1.06339

3.29E-06

1.593842

4.40E-05

0.70307

3.14E-06

0.605171

70.0651; 41.0386

13

Spermine

C10H26N4

13.76

241.18

1.05343

4.59E-05

2.891314

0.077649

0.785466

8.89E-05

0.389801

58.0657; 186.1970

14

4-Hydroxyphenylpyruvic acid

C9H8O4

3.68

181.0491

1.19548

0.000492

2.762776

0.011312

0.58101

0.000701

0.392195

77.0391; 107.0497

15

Diaminopimelic acid

C7H14N2O4

0.79

213.0852

1.8311

1.40E-09

2.180373

9.35E-06

0.565259

7.44E-10

0.411171

82.0652; 128.0705

16

LysoPC(P-16:0/0:0)

C24H50NO6P

19

480.3413

1.87704

1.64E-06

0.514088

0.003854

1.339187

3.65E-06

1.649673

180.0188; 462.3343

17

Leukotriene C4

C30H47N3O9S

12.14

626.3128

1.31377

7.35E-08

0.286374

0.024872

1.351636

3.93E-07

2.82934

189.1638; 319.2268

18

LysoPE(0:0/18:2(9Z,12Z))

C23H44NO7P

16.79

478.2935

1.615482

0.002276

1.730487

0.000351

0.530287

2.76E-05

0.393158

263.2369; 337.2737

19

PGP(18:0/18:2(9Z,12Z))

C42H80O13P2

29.14

872.5415

1.854269

3.27E-06

2.225789

0.000646

0.628777

1.16E-06

0.394302

603.5347; 757.5378

20

Anileridine

C22H28N2O2

18.7

353.2236

1.5043

4.90E-07

2.232817

0.004675

0.783746

1.08E-05

0.600209

120.0808; 279.1856

21

4-Oxoretinal

C20H26O2

13.32

299.2014

1.25101

0.000157

1.724575

0.008411

0.73029

3.73E-06

0.487338

137.0961; 189.1274

22

LysoPE(0:0/20:0)

C25H52NO7P

19.76

510.3511

2.43664

9.46E-09

0.428477

0.000292

1.721601

4.79E-07

2.180142

44.0495; 369.3363

23

LysoPE(0:0/22:0)

C27H56NO7P

23.79

538.3835

1.752036

0.000226

0.435181

0.009919

1.432045

3.59E-06

2.272196

44.0495; 397.3676

24

LysoPG(16:0/0:0)

C22H45O9P

21.28

483.2727

4.0505

0.000257

0.438891

2.68E-05

1.515575

2.20E-08

2.256267

483.2728

25

Cholic acid

C24H40O5

13.08

407.2826

2.24678

1.49E-14

0.315424

2.92E-09

2.107035

3.85E-10

3.146423

345.2794; 373.2743

26

Prostaglandin A2

C20H30O4

14.39

333.2069

1.57342

1.37E-11

0.391936

0.004173

1.707462

4.52E-06

2.156729

67.0542; 299.2006

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