Genetic analysis reveals the inconsistency of amorpha-4,11-diene synthase, a key enzyme in the artemisinin synthesis pathway, in asteraceae

Table 2 Estimated Ka/Ks ratios of the ADS genes in A. annua

No	Sequence	Ka	Ks	Ka/Ks	Date (millions of years ago)
1	p0_ADS.1&p0_ADS.2	0.00298	0.00006	46.06050	0.0035
2	p0_ADS.1&p0_ADS.3	0.00314	0.00555	0.56649	0.3010
3	p0_ADS.1&p0_ADS.4	0.00393	0.00555	0.70743	0.3014
4	p0_ADS.1&p1_ADS.5	0.00142	0.00003	47.76480	0.0016
5	p0_ADS.1&p1_ADS.6	0.00223	0.00005	48.59900	0.0025
6	p0_ADS.1&p1_ADS.7	0.00235	0.00833	0.28257	0.4524
7	p0_ADS.1&p1_ADS.8	0.00314	0.00834	0.37674	0.4526
8	p0_ADS.2&p0_ADS.3	0.00157	0.00554	0.28312	0.3009
9	p0_ADS.2&p0_ADS.4	0.00393	0.00555	0.70785	0.3013
10	p0_ADS.2&p1_ADS.5	0.00155	0.00004	42.07890	0.0020
11	p0_ADS.2&p1_ADS.6	0.00072	0.00001	48.92730	0.0008
12	p0_ADS.2&p1_ADS.7	0.00078	0.00833	0.09415	0.4522
13	p0_ADS.2&p1_ADS.8	0.00314	0.00833	0.37696	0.4524
14	p0_ADS.3&p0_ADS.4	0.00393	0.01114	0.35261	0.6048
15	p0_ADS.3&p1_ADS.5	0.00195	0.00413	0.47162	0.2240
16	p0_ADS.3&p1_ADS.6	0.00078	0.00555	0.14140	0.3010
17	p0_ADS.3&p1_ADS.7	0.00078	0.00833	0.09415	0.4522
18	p0_ADS.3&p1_ADS.8	0.00314	0.01394	0.22533	0.7568
19	p0_ADS.4&p1_ADS.5	0.00393	0.00556	0.70659	0.3017
20	p0_ADS.4&p1_ADS.6	0.00314	0.00555	0.56565	0.3014
21	p0_ADS.4&p1_ADS.7	0.00314	0.01395	0.22513	0.7574
22	p0_ADS.4&p1_ADS.8	0.00078	0.00277	0.28291	0.1504
23	p1_ADS.5&p1_ADS.6	0.00083	0.00002	46.77650	0.0010
24	p1_ADS.5&p1_ADS.7	0.00078	0.00834	0.09398	0.4528
25	p1_ADS.5&p1_ADS.8	0.00314	0.00835	0.37629	0.4530
26	p1_ADS.6&p1_ADS.7	0.00001	0.01021	0.0010	0.5545
27	p1_ADS.6&p1_ADS.8	0.00243	0.00999	0.24309	0.5422
28	p1_ADS.7&p1_ADS.8	0.00252	0.02083	0.1209	1.1309

ISSN: 1749-8546