Fig. 4

A and B Partial least squares discriminant analysis (PLS-DA) score plots of mice pulmonary lipids among control, LPS, and LPS + PAE groups. N = 6, per group: A positive ion mode; B negative ion mode. C and D ChemRICH enrichment plots of differential lipids screened in C LPS vs Control and D LPS + PAE (7.55 g/kg/d) vs LPS groups. The size of each circle was proportionate to the number of lipids in the same class. Red colour represented up-regulation, blue colour represented down-regulation, and purple colour represented up or down-regulation, respectively. E and F Heatmap of differential lipids that up-regulated in LPS vs Control group while downregulated in LPS + PAE (7.55 g/kg/d) vs LPS groups: E positive ion mode and F negative ion mode. Each square in the heatmap represents the corresponding average intensity value of a lipid of samples in each group, red squares represent an increase in concentration and blue ones represent a decrease in concentration. G The concentration of phosphatidylinositol in lung tissues of mice among control, model, and LPS + PAE (7.55 g/kg/d). ^*P < 0.05 compared with the control group; ^#P < 0.05 compared with the LPS group