A review on the effect of garlic on diabetes, BDNF, and VEGF as a potential treatment for diabetic retinopathy

Chinese Medicine

Table 1 Molecular formula, chemical structure and some pharmacokinetic parameters of some garlic -derived organosulfurs^a

OSCs	MF	RT (min)	HIA%	BBBP	pKa1 (acidic)	pKa2 (basic)	RB	TPSA	Tm	TE
S-allyl-l-cysteine	C6H11NO2S	3.93	81.972	No	2.53	9.14	5	88.62	7.758	6.222
Alliin	C6H11NO3S	3.71	73.041	No	1.84	8.45	5	99.60	8.386	11.192
Diallyl disulfide	C6H10S2	16.68	98.169	Yes	b	b	5	50.60	6.75	3.512
E-Ajoene	C9H14OS3	7.46	99.314	No	14.9	b	8	86.88	16.744	10.291
Z-Ajoene	C9H14OS3	7.41	99.314	No	14.9	b	8	86.88	13.945	10.421
Diallyl sulfide	C6H10S	9.71	100.000	Yes	b	b	4	25.30	6.067	3.223
Allicin	C6H10OS2	5.06	98.312	Yes	b	b	5	61.58	6.92	6.924
Diallyl Trisulfide	C6H10S3	25.6	98.996	Yes	b	b	6	75.90	8.334	3.549

BBBP blood–brain barrier permeation, ChS chemical structure, HIA human gastrointestinal absorption, MF molecular formula, OSCs organosulfur compound, RB Rotatable bonds, RT Retention time, TE topographic electronic descriptor, Tm total size index/weighted by mass, TPSA topological polar surface area
^aFor more information please see the work by Ramirez et al.[12]
^bNon-ionizable compound

ISSN: 1749-8546