Fig. 4

Effect on p38 MAPK, Bax and Bcl-2 in heart tissue. Mice were administered with RAF-L (25 mg/kg, i.g.), RAF-M (50 mg/kg, i.g.), RAF-H (100 mg/kg, i.g.) or 0.5% CMC-Na (i.g.) for 7 days. The expressions of p38 MAPK, Bax and Bcl-2 were analyzed by qRT-PCR (A) and immunofluorescence staining (B–D). Data are represented as the mean ± SEM of 3 mice per group. ^*P < 0.05, ^**P < 0.01, and ^***P < 0.001 compared with the Model group